General Information of Drug (ID: DMHIDCJ)

Drug Name
Octreotide
Synonyms
Longastatin; Octreotida; Octreotidum; Sandostatine; Octreotida [Spanish]; Octreotide Acetate Salt; Octreotidum [Latin]; DRG-0115; HS-2020; Octreotide-LAR; SAN 201-995; SM 201-995; SMS 201-995; Sandostatin (TN); Sandoz 201-995; Octreotide (USAN/INN); Octreotide [USAN:INN:BAN]; SMS-201-995; Zacycloicosane-4-carboxamide acetate; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide; L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide; 10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa;10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide; 10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Indication
Disease Entry ICD 11 Status REF
Acromegaly 5A60.0 Approved [1]
Carcinoid syndrome 5B10 Approved [2]
Diabetic retinopathy 9B71.0 Approved [2]
Neuroendocrine cancer 2B72.1 Investigative [2]
Therapeutic Class
Anabolic Agents
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 4 Molecular Weight (mw) 1019.2
Logarithm of the Partition Coefficient (xlogp) 1
Rotatable Bond Count (rotbonds) 17
Hydrogen Bond Donor Count (hbonddonor) 13
Hydrogen Bond Acceptor Count (hbondacc) 14
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1.67C2.5 h [3]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [4]
Clearance
The total body clearance of drug is 7-10 L/h [3]
Elimination
About 32% of an oral octreotide dose is excreted into the urine and 30-40% is excreted by the liver into the feces [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 0.2 hours [3]
Metabolism
The drug is metabolized via the liver [5]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.021 micromolar/kg/day [6]
Unbound Fraction
The unbound fraction of drug in plasma is 0.35% [7]
Vd
The volume of distribution (Vd) of drug is 13.6 L [3]
Chemical Identifiers
Formula
C49H66N10O10S2
IUPAC Name
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Canonical SMILES
C[C@H]([C@H]1C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)NC(=O)[C@@H](CC5=CC=CC=C5)N)C(=O)N[C@H](CO)[C@@H](C)O)O
InChI
InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)/t28-,29-,34-,36+,37+,38-,39-,40+,41+,42+/m1/s1
InChIKey
DEQANNDTNATYII-OULOTJBUSA-N
Cross-matching ID
PubChem CID
448601
CAS Number
83150-76-9
DrugBank ID
DB00104
TTD ID
D02XIY
VARIDT ID
DR01163
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Somatostatin receptor type 2 (SSTR2) TTZ6T9E SSR2_HUMAN Binder [8]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [10]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [11]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [12]
Cholecystokinin (CCK) OT1GCG0L CCKN_HUMAN Protein Interaction/Cellular Processes [13]
Glycoprotein hormones alpha chain (CGA) OT00U3Y3 GLHA_HUMAN Protein Interaction/Cellular Processes [14]
Insulin (INS) OTZ85PDU INS_HUMAN Gene/Protein Processing [15]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Gene/Protein Processing [16]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Gene/Protein Processing [17]
Somatostatin (SST) OTY75GQH SMS_HUMAN Protein Interaction/Cellular Processes [11]
Somatotropin (GH1) OT92RTRD SOMA_HUMAN Gene/Protein Processing [18]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Acromegaly
ICD Disease Classification 5A60.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Somatostatin receptor type 2 (SSTR2) DTT SSTR2 9.79E-07 -0.38 -0.65
Multidrug resistance-associated protein 2 (ABCC2) DTP MRP2 7.16E-01 -1.28E-02 -6.06E-02
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Octreotide (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Methylergonovine DMBEX4O Moderate Decreased metabolism of Octreotide caused by Methylergonovine mediated inhibition of CYP450 enzyme. Abortion [JA00] [19]
Gilteritinib DMTI0ZO Moderate Decreased metabolism of Octreotide caused by Gilteritinib mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [20]
Pexidartinib DMS2J0Z Major Decreased metabolism of Octreotide caused by Pexidartinib mediated inhibition of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [21]
Palbociclib DMD7L94 Moderate Decreased metabolism of Octreotide caused by Palbociclib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [20]
Dofetilide DMPN1TW Moderate Decreased metabolism of Octreotide caused by Dofetilide mediated inhibition of CYP450 enzyme. Cardiac arrhythmia [BC9Z] [22]
PF-04449913 DMSB068 Moderate Decreased metabolism of Octreotide caused by PF-04449913 mediated inhibition of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [23]
Mifepristone DMGZQEF Moderate Decreased metabolism of Octreotide caused by Mifepristone mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [24]
Ripretinib DM958QB Moderate Decreased metabolism of Octreotide caused by Ripretinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [25]
Avapritinib DMK2GZX Moderate Decreased metabolism of Octreotide caused by Avapritinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [20]
177Lu-DOTATATE DMT8GVU Moderate Interference of cell/tissue uptake of Octreotide by 177Lu-DOTATATE. Hepatitis virus infection [1E50-1E51] [26]
MK-1439 DM215WE Minor Decreased metabolism of Octreotide caused by MK-1439 mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [27]
Etravirine DMGV8QU Moderate Decreased metabolism of Octreotide caused by Etravirine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [28]
Lurbinectedin DMEFRTZ Moderate Decreased metabolism of Octreotide caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [29]
PF-06463922 DMKM7EW Moderate Decreased metabolism of Octreotide caused by PF-06463922 mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [30]
Pralsetinib DMWU0I2 Moderate Decreased metabolism of Octreotide caused by Pralsetinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [31]
Selpercatinib DMZR15V Moderate Decreased metabolism of Octreotide caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [20]
IPI-145 DMWA24P Moderate Decreased metabolism of Octreotide caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [32]
Acalabrutinib DM7GCVW Moderate Decreased metabolism of Octreotide caused by Acalabrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [33]
Ibrutinib DMHZCPO Moderate Decreased metabolism of Octreotide caused by Ibrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [34]
Methysergide DM1EF73 Moderate Decreased metabolism of Octreotide caused by Methysergide mediated inhibition of CYP450 enzyme. Migraine [8A80] [19]
Dihydroergotamine DM5IKUF Moderate Decreased metabolism of Octreotide caused by Dihydroergotamine mediated inhibition of CYP450 enzyme. Migraine [8A80] [35]
Ruxolitinib DM7Q98D Minor Decreased metabolism of Octreotide caused by Ruxolitinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [20]
Oxycodone DMXLKHV Moderate Decreased metabolism of Octreotide caused by Oxycodone mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [25]
Istradefylline DM20VSK Moderate Decreased metabolism of Octreotide caused by Istradefylline mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [36]
Bromocriptine DMVE3TK Moderate Decreased metabolism of Octreotide caused by Bromocriptine mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [37]
Lefamulin DME6G97 Moderate Decreased metabolism of Octreotide caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [38]
Ergonovine DM0VEC1 Moderate Decreased metabolism of Octreotide caused by Ergonovine mediated inhibition of CYP450 enzyme. Postpartum haemorrhage [JA43] [19]
Lonafarnib DMGM2Z6 Major Decreased metabolism of Octreotide caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [39]
Darolutamide DMV7YFT Minor Decreased metabolism of Octreotide caused by Darolutamide mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [40]
Everolimus DM8X2EH Moderate Decreased metabolism of Octreotide caused by Everolimus mediated inhibition of CYP450 enzyme. Renal cell carcinoma [2C90] [41]
Upadacitinib DM32B5U Moderate Decreased metabolism of Octreotide caused by Upadacitinib mediated inhibition of CYP450 enzyme. Rheumatoid arthritis [FA20] [42]
Fentanyl DM8WAHT Moderate Decreased metabolism of Octreotide caused by Fentanyl mediated inhibition of CYP450 enzyme. Sensation disturbance [MB40] [43]
Larotrectinib DM26CQR Moderate Decreased metabolism of Octreotide caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [25]
⏷ Show the Full List of 33 DDI Information of This Drug

References

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