Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJKH28)

Drug Name

PD-144418 Drug Info

Synonyms

PD144418; PD 144418; ZINC5862; GTPL10731; BDBM50251208; AKOS024457192; NCGC00378668-01; HY-108512; CS-0029071; Q27456166

Indication

Disease Entry	ICD 11	Status	REF
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[1]

Therapeutic Class

Antiviral Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting HUMAN opioid receptor sigma 1 (OPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[2]
PB28	DMMNQ1B	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]
E-52862	DMLZU09	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]
RS-PPCC	DMN3ZOD	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HUMAN opioid receptor sigma 1 (OPRS1)	TTTPE1L	SGMR1_HUMAN	Antagonist	[2]

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References

1	The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology. 1997 Jan;36(1):51-62.
2	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing