Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJKZUC)

Drug Name

NC-2100 Drug Info

Synonyms

NC-2100; nc2100; SCHEMBL377641; NC 2100; 179068-64-5; 2,4-Thiazolidinedione, 5-((7-(phenylmethoxy)-3-quinolinyl)methyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Mitochondrial uncoupling protein 2 (UCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CL-316,243	DMXH1KC	Obesity	5B81	Phase 2	[2]
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Drug(s) Targeting Mitochondrial uncoupling protein 1 (UCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CL-316,243	DMXH1KC	Obesity	5B81	Phase 2	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mitochondrial uncoupling protein 1 (UCP1)	TTI12YJ	UCP1_HUMAN	Inducer	[1]
Mitochondrial uncoupling protein 2 (UCP2)	TTSC2YM	UCP2_HUMAN	Inducer	[1]

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References

1	A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes. 2000 May;49(5):759-67.
2	Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37.