Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJUV6C)

Drug Name

BMS-223131 Drug Info

Synonyms

4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)quinolin-2(1H)-one

Indication

Disease Entry	ICD 11	Status	REF
Erectile dysfunction	HA01.1	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Charybdotoxin receptor beta-4 (BKbeta4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NS-1619	DMES0OT	Asthma	CA23	Terminated	[2]
CNS-1237	DMP3QAZ	Cerebrovascular ischaemia	8B1Z	Terminated	[3]
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[4]
iberiotoxin	DMRIG3O	Discovery agent	N.A.	Investigative	[4]
paxilline	DMPF2N1	Discovery agent	N.A.	Investigative	[5]
slotoxin	DMBD6TC	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Charybdotoxin receptor beta-4 (BKbeta4)	TT1AQ50	KCMB4_HUMAN	Modulator	[1]

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References

1	Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance ... J Pharmacol Exp Ther. 2005 May;313(2):840-7.
2	BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery
3	Effects of Ca2+ and Na+ channel inhibitors in vitro and in global cerebral ischaemia in vivo. Eur J Pharmacol. 1997 Aug 6;332(2):121-31.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 380).
5	Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology. 1996;35(7):963-8.
6	Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha+beta (beta1 or beta4) complexes. FEBS Lett. 2001 Sep 21;505(3):369-73.