Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK9743)

Drug Name

Trimetoquinol Drug Info

Synonyms

Trimetoquinol; Trimethoquinol; Inolin; Trimetoquinol-hydrochloride; AQL 208; Trikvinol (triquinol) hydrochloride; l-Trimetoquinol; Trimetoquinol (VAN); Trimethoquinol (VAN); AQ-110; CCRIS 1913; Tretoquinol l-form hydrochloride; Tetroquinol; EINECS 242-423-5; NSC 288748; TRETOQUINOL HYDROCHLORIDE; (-)-Trimethoquinol; AC1L1GTS; C19H23NO5.HCl; CHEMBL542101; SCHEMBL1630263; L-1-(3,4,5-Trimethylbenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; AQL-208; 1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydroch

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 29137
CAS Number: CAS 18559-63-2
TTD Drug ID: DMK9743

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Adrenergic receptor beta-3 (ADRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mirabegron	DMS1GYT	Overactive bladder	GC50.0	Approved	[2]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[3]
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[4]
Bopindolol	DMIFYLX	Hypertension	BA00-BA04	Approved	[5]
Mepindolol	DMUDWP9	Angina pectoris	BA40	Approved	[6]
Rimiterol	DMA47C6	Asthma	CA23	Approved	[7]
Bitolterol	DMK6XAV	Chronic obstructive pulmonary disease	CA22	Approved	[8]
Nipradilol	DMA65ER	Angina pectoris	BA40	Approved	[9]
Vibegron	DMFR201	Overactive bladder	GC50.0	Approved	[10]
ONO-2506	DMCA2PJ	Stroke	8B20	Phase 2/3	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-3 (ADRB3)	TTMXGCW	ADRB3_HUMAN	Agonist	[1]

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References

1	Synthesis and human beta-adrenoceptor activity of 1-(3,5-diiodo-4- methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol derivatives in vitro. J Med Chem. 2000 Feb 24;43(4):591-8.
2	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
3	Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
4	Effects of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on ischemic myocardial energy metabolism in dogs. J Pharm Sci. 1993 Mar;82(3):291-5.
5	Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes. J Cardiovasc Pharmacol. 1986;8 Suppl 6:S70-3.
6	Pharmacological studies on the intrinsic sympathomimetic activity of the beta-adrenoceptor antagonist mepindolol. Arzneimittelforschung. 1986 May;36(5):811-3.
7	Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man. Br J Clin Pharmacol. 1975 Feb;2(1):41-8.
8	Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma. Pharmacotherapy. 1985 May-Jun;5(3):127-37.
9	Actions of nipradilol (K-351), a new alpha- and beta-adrenoceptor blocker, on the rabbit portal vein. Jpn J Pharmacol. 1984 Aug;35(4):359-69.
10	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
11	FR149175, a beta 3-adrenoceptor-selective agonist, is a possible therapeutic agent for non-insulin-dependent diabetes mellitus. Jpn J Pharmacol. 1997 May;74(1):109-12.