General Information of Drug (ID: DMKCXBJ)

Drug Name
SDZ-MTH-958 Drug Info
Synonyms IDDB8852
Indication
Disease Entry ICD 11 Status REF
Artery stenosis BD52 Terminated [1]
Cross-matching ID
TTD Drug ID
DMKCXBJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nafamostat DMU1XOD Pancreatitis DC31-DC34 Approved [3]
Gabexate DMU9D2F Pancreatitis DC31-DC34 Approved [3]
Aprotinin DM0QD4W Bleeding disorder GA20-GA21 Approved [4]
Sivelestat sodium hydrate DMOSJD0 Acute lung injury NB32.3 Phase 4 [5]
Camostat DMQ7UL8 Cystic fibrosis CA25 Phase 2 [6]
VT-111a DMY9ZGN Acute coronary syndrome BA41 Phase 2 [7]
Sepimostat mesylate DMRBYH8 Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 3 [8]
VT-111 DMOY15R Graft rejection in heart transplantation NE84 Preclinical [9]
NPI-1999 DMH1YL8 Thrombosis DB61-GB90 Terminated [10]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine protease unspecific (SP) TTEMV5X NOUNIPROTAC Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005235)
2 Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection. Transplantation. 1996 Mar 27;61(6):862-8.
3 Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients. Int J Oncol. 2009 Jul;35(1):115-20.
4 Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding Clin Trials. 2005;2(3):218-29; discussion 229-32.
5 Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
6 Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. J Hypertens. 2009 Jan;27(1):181-9.
7 Viral Serpin Therapeutics: From Concept to Clinic. Methods Enzymol. 2011; 499: 301-329.
8 Effect of FUT-187, oral serine protease inhibitor, on inflammation in the gastric remnant. Gan To Kagaku Ryoho. 1996 Dec;23(14):1971-9.
9 New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
10 US patent application no. 2005,0096,323, Diketopiperazine derivatives to inhibit thrombin.