General Information of Drug (ID: DMKM3WJ)

Drug Name
cholesten Drug Info
Synonyms cholestane; cholestan; alpha-cholestane
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6857534
ChEBI ID
CHEBI:35516
CAS Number
CAS 14982-53-7
TTD Drug ID
DMKM3WJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [3]
Guggulsterone DMP7LK1 Osteoarthritis FA00-FA05 Approved [4]
Obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [5]
Bevacizumab + Trastuzumab DM9CEI5 Breast cancer 2C60-2C65 Phase 3 [3]
GS-9674 DM936V7 Primary sclerosing cholangitis DB96.2 Phase 3 [6]
Apomine DM6B9HP Osteopetrosis LD24.10 Phase 2 [7]
LJN452 DM3XRUH Primary biliary cholangitis DB96.1 Phase 2 [8]
EYP001 DM5PBLM Non-alcoholic steatohepatitis DB92.1 Phase 2 [9]
EDP-305 DMGJYZ8 Non-alcoholic steatohepatitis DB92.1 Phase 2 [10]
LMB763 DMQOXNL Diabetic nephropathy GB61.Z Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Farnesoid X-activated receptor (FXR) TTS4UGC NR1H4_HUMAN Agonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2802).
2 Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol Cell Biol. 2003 Feb;23(3):864-72.
3 Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J Biol Chem. 2002 Aug 30;277(35):31441-7.
4 Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia. J Nat Prod. 2009 Jan;72(1):24-8.
5 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
6 The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis. Hepatology. 2019 Sep;70(3):788-801.
7 The nuclear receptors FXR and LXRalpha: potential targets for the development of drugs affecting lipid metabolism and neoplastic diseases. Curr Pharm Des. 2001 Mar;7(4):231-59.
8 FXR modulators for enterohepatic and metabolic diseases.Expert Opin Ther Pat. 2018 Nov;28(11):765-782.
9 Clinical pipeline report, company report or official report of ENYO Pharma.
10 A novel non-bile acid FXR agonist EDP-305 potently suppresses liver injury and fibrosis without worsening of ductular reaction. Liver Int. 2020 Jul;40(7):1655-1669.
11 Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Apr 23;63(8):3868-3880.