Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKRG2C)

Drug Name

Thiadiazolo[2,3-a]pyrimidine Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Virus RNA-dependent RNA polymerase (Viru RdRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-527	DMARIQK	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[2]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[3]
Guanosine-5'-Triphosphate	DMV2OJX	Discovery agent	N.A.	Investigative	[4]
T-1105	DMGPQ0Y	Discovery agent	N.A.	Investigative	[1]
Pyrimidinyl acylthiourea	DM7T2VQ	Discovery agent	N.A.	Investigative	[1]
FdG	DMYXA7E	Discovery agent	N.A.	Investigative	[1]
T-1106	DMPA2E9	Virus infection	1A24-1D9Z	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Virus RNA-dependent RNA polymerase (Viru RdRP)	TTSUKYD	POLG_HCVJA	Inhibitor	[1]

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References

1	Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9.
2	AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02479-20.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.