Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKTQB2)

Drug Name

2-Methyl-1(3)H-anthrasimidazole-6,11-dione Drug Info

Synonyms

AC1MZY8L; CHEMBL594892; SCHEMBL17702673; MolPort-002-517-242; MolPort-000-752-121; ZINC9353066; AKOS030496241; MCULE-7367469235; 2-methyl-3H-naphtho[3,2-e]benzimidazole-6,11-dione

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3908369
TTD Drug ID: DMKTQB2

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting TERT messenger RNA (TERT mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[2]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[2]
2,7-Bis(acetamido)anthraquinone	DM2EPM4	Discovery agent	N.A.	Investigative	[3]
2,7-Bis(cyclohexanecarbonamido)anthraquinone	DMTPZ8D	Discovery agent	N.A.	Investigative	[3]
2,7-Bis[2-(isopropylamino)acetamido]anthraquinone	DMRQGWX	Discovery agent	N.A.	Investigative	[3]
NSC-745884	DM8W0J3	Discovery agent	N.A.	Investigative	[1]
2,7-Bis[3-(piperidino)propionamido]anthraquinone	DMET693	Discovery agent	N.A.	Investigative	[3]
2,7-Bis(cyclopropanecarbonamido)anthraquinone	DMY3V2B	Discovery agent	N.A.	Investigative	[3]
2,7-Bis(phenylacetamido)anthraquinone	DMEVIBT	Discovery agent	N.A.	Investigative	[3]
NSC-745887	DMG9BWY	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TERT messenger RNA (TERT mRNA)	TTQY2EJ	TERT_HUMAN	Inhibitor	[1]

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References

1	Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28.
2	Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
3	Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86.