Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKTZSY)

Drug Name

1-(2'-chlorophenyl)penta-1,4-dien-3-one Drug Info

Synonyms

CHEMBL224976; BDBM50177103; 1,4-Pentadien-3-one, 1-(2-chlorophenyl)-; 1-(2''-chlorophenyl)penta-1,4-dien-3-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Glutathione reductase (GR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[2]
Golden phosphorous acetyletic compound 2	DMYJ15A	N. A.	N. A.	Patented	[3]
Terpyridineplatinum(II) complexe 3	DM54EFD	N. A.	N. A.	Patented	[3]
Terpyridineplatinum(II) complexe 4	DMOV86T	N. A.	N. A.	Patented	[3]
Golden phosphorous acetyletic compound 1	DMVAKUI	N. A.	N. A.	Patented	[3]
Acyl oxymethyl acrylamide ester derivative 1	DMXTUE1	N. A.	N. A.	Patented	[3]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[4]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[4]
3-Sulfinoalanine	DMILTRN	N. A.	N. A.	Investigative	[4]
Trans-(R(S))-2-Hydroxy-1-phenylethyl nitrate	DMXC98D	Discovery agent	N.A.	Investigative	[5]
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Drug(s) Targeting Trypanosoma Trypanothione reductase (Trypano TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[6]
Bivalirudin	DMECRX1	Thrombocytopenia	3B64	Approved	[7]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[4]
CONESSINE	DM4VYP0	Discovery agent	N.A.	Investigative	[8]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[9]
CEPHARANTINE	DMCE3NA	Discovery agent	N.A.	Investigative	[8]
Trypanothione	DMDUGQ1	Discovery agent	N.A.	Investigative	[4]
N-(5-chloro-2-(phenylthio)phenyl)butyramide	DMHZ256	Discovery agent	N.A.	Investigative	[10]
N1,N2-bis(dihydrocaffeoyl)spermine	DMSDVGQ	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutathione reductase (GR)	TTEP6RV	GSHR_HUMAN	Inhibitor	[1]
Trypanosoma Trypanothione reductase (Trypano TPR)	TTRTKPV	TYTR_TRYBB	Inhibitor	[1]

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References

1	Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10.
2	The purification and properties of glutathione reductase from the cestode Moniezia expansa. Int J Biochem Cell Biol. 1995 Apr;27(4):393-401.
3	Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3661-3.
6	Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
7	8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase. Mem Inst Oswaldo Cruz. 2003 Jun;98(4):565-8.
8	The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. Bioorg Med Chem. 2008 Jul 15;16(14):6689-95.
9	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
10	Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class ... J Med Chem. 2005 Dec 15;48(25):8087-97.