Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML09OS)

Drug Name

GRL-0667 Drug Info

Synonyms

BDBM50007789; CHEMBL1173044; GRM; Q27460878; SCHEMBL7938638

Indication

Disease Entry	ICD 11	Status	REF
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[1]

Therapeutic Class

Antiviral Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting SARS-CoV papain-like proteinase (PL-PRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[2]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[3]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[3]
PMID20527968-compound-6577871	DMI30V7	Severe acute respiratory syndrome (SARS)	1D65	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SARS-CoV papain-like proteinase (PL-PRO)	TTRGHB2	R1AB_CVHSA (819-2740)	Inhibitor	[1]

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References

1	Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biologic... J Med Chem. 2010 Jul 8;53(13):4968-79.
2	Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150.
3	Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antiviral Res. 2015 Mar;115:9-16.