Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML32R8)

Drug Name

VX-148 Drug Info

Synonyms

VX-148; SCHEMBL12343182; BDBM248095; VX-148 (3)

Indication

Disease Entry	ICD 11	Status	REF
Psoriasis vulgaris	EA90	Patented	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[4]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[5]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Mizoribine	DMW6F0S	Transplant rejection	NE84	Approved	[5]
Viramidine	DMJFNR9	Hepatitis C virus infection	1E51.1	Phase 3	[7]
VX-944	DME321B	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
PMID28074661-Compound-US20100022547C81	DMM9E1U	N. A.	N. A.	Patented	[8]
PMID28074661-Compound-US20120264760C80	DM75QVW	N. A.	N. A.	Patented	[8]
Carbamide derivative 9	DMY06VC	N. A.	N. A.	Patented	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)	TTL7C8Q	IMDH1_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013965)
2	Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7.
3	Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67.
4	Treating HCV with ribavirin analogues and ribavirin-like molecules. J Antimicrob Chemother. 2006 Jan;57(1):8-13.
5	VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37.
6	In vitro and in vivo antiproliferative activity of IPCAR, a new pyrazole nucleoside analog. Anticancer Res. 1998 Jul-Aug;18(4A):2623-30.
7	Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
8	Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.