Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML4PMG)

Drug Name

Dendritic cell vaccine Drug Info

Synonyms

Dendritic cell vaccine, University of Bonn; Human telomerase reverse transcriptase (hTERT)-pulsed dendritic cells (cancer), University of Bonn

Indication

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[3]
GV1001	DMHULRK	Pancreatic cancer	2C10	Phase 3	[4]
Imetelstat	DMONWJ4	Myelodysplastic syndrome	2A37	Phase 2/3	[5]
VM1500A	DM9YSSY	Human immunodeficiency virus-1 infection	1C62	Phase 2/3	[6]
GRNVAC1	DMAHOEP	Acute myeloid leukaemia	2A60	Phase 2	[7]
Vx-001	DMDKWA3	Breast cancer	2C60-2C65	Phase 2	[8]
CB-10-01	DM2IFYZ	Melanoma	2C30	Phase 2	[9]
Epithalon	DMWSGZU	Ocular inflammation	9C61.24	Phase 1/2	[10]
OBP-301	DM9MF08	Breast cancer	2C60-2C65	Phase 1/2	[11]
KML-001	DM1D2O0	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Telomerase reverse transcriptase (TERT)	TTUJFD0	TERT_HUMAN	Not Available	[2]

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References

1	Dendritic cell-targeted vaccines--hope or hype. Nat Rev Immunol. 2014 Oct;14(10):705-11.
2	In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. J Immunotoxicol. 2009 Dec;6(4):243-8.
3	Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine. Parasitol Int. 2002 Mar;51(1):99-103.
4	Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. Br J Cancer. 2006 Dec 4;95(11):1474-82.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida(?)) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1056-1060.
7	Targeting telomerase-expressing cancer cells. J Cell Mol Med. 2011 Jul;15(7):1433-42.
8	Clinical pipeline report, company report or official report of Vaxon-biotech.
9	Telomerase immunity from bench to bedside: round one. J Transl Med. 2007 Feb 26;5:12.
10	Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.
11	Telomerase-specific replication-selective virotherapy for human cancer. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):285-92.
12	National Cancer Institute Drug Dictionary (drug id 672554).