Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML5FQT)

Drug Name

1-methyl-1H-indole-3-carbonitrile Drug Info

Synonyms

1-Methyl-1H-indole-3-carbonitrile; 24662-37-1; 1-methylindole-3-carbonitrile; 3-Cyano-1-methylindole; 1H-Indole-3-carbonitrile, 1-methyl-; 1H-Indole-3-carbonitrile,1-methyl-; CHEMBL205035; F9995-1129; AC1M4H5X; SCHEMBL1778037; 3-Cyano(1-methyl-1H-indole); CTK4F4137; FBAXZPMXGBNBPE-UHFFFAOYSA-; DTXSID30367996; MolPort-000-002-609; FBAXZPMXGBNBPE-UHFFFAOYSA-N; HMS1753J21; ZINC3165608; BDBM50182877; STK386450; MFCD00466602; AKOS001015339; MCULE-7170650231; AS-9400; AJ-44684; KB-12784; DA-07730; ST50875554; AM20040004; FT-0719960

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2307681
CAS Number: CAS 24662-37-1
TTD Drug ID: DML5FQT

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[2]
Urea and carbamate bioisostere derivative 1	DMEQFXZ	N. A.	N. A.	Patented	[3]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[4]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[4]
Mycophenolic hydroxamic acid	DM4YRAH	Discovery agent	N.A.	Investigative	[5]
Tiazofurin adenine dinucleotide	DMEFVPH	Discovery agent	N.A.	Investigative	[6]
Mycophenolic bis(sulfonamide)	DMUQP3J	Discovery agent	N.A.	Investigative	[7]
6-Chloropurine Riboside, 5'-Monophosphate	DMWB43U	Discovery agent	N.A.	Investigative	[4]
1-methyl-1H-indole-3-carboxamide	DMUKAH6	Discovery agent	N.A.	Investigative	[8]
6-phenyl-3-(pyridin-4-yl)-1H-indole	DM3UBR5	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)	TTTB4UP	IMDH2_HUMAN	Inhibitor	[1]

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References

1	Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42.
2	Clinical pipeline report, company report or official report of Roche (2009).
3	Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11.
6	Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. J Med Chem. 2007 Dec 27;50(26):6685-91.
7	Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9.
8	Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8.