General Information of Drug (ID: DML6OE7)

Drug Name
Tbo-Filgrastim Drug Info
Synonyms Neutroval (TN)
Indication
Disease Entry ICD 11 Status REF
Neutropenia 4B00.0 Approved [1]
Cross-matching ID
TTD Drug ID
DML6OE7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pegfilgrastim DM7UP8X Central nervous system neoplasm Approved [3]
Peg-G-CSF DMBKWAF Solid tumour/cancer 2A00-2F9Z Phase 3 [4]
BLZ-945 DMG1LVA Amyotrophic lateral sclerosis 8B60.0 Phase 2 [4]
SBC-014 DMG1VXR Neutropenia 4B00.0 Phase 2 [5]
AX-200 DMTAEMB Cardiovascular disease BA00-BE2Z Phase 2 [6]
MAXY-G34 DMWLIPJ Neutropenia 4B00.0 Phase 2 [7]
PLX7486 DM0IVGU Pancreatic cancer 2C10 Phase 1 [8]
AMG 820 DMB6Q19 Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
MK-6302 DMZUA5C Neutropenia 4B00.0 Phase 1 [10]
PLX-5622 DMK4PWM Autoimmune diabetes 5A10 Phase 1 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Granulocyte colony-stimulating factor receptor (G-CSF-R) TTC70AJ CSF3R_HUMAN Modulator [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6968).
2 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
3 Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model. Pharmacol Res. 2004 Jul;50(1):55-8.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).
5 A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study. BMC Clin Pharmacol. 2009; 9: 2.
6 Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for Ischemic Stroke trial. Stroke. 2013 Oct;44(10):2681-7.
7 Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors. Health Phys. 2014 Jan;106(1):21-38.
8 National Cancer Institute Drug Dictionary (drug id 747694).
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636.
11 Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling. Mol Med. 2012; 18(1): 519-527.