Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLCXPD)

Drug Name
TG-C Drug Info
Synonyms
3-Thiaglutaryl-Coa; S-[[(2-Hydroxy-2-oxoethyl)thio]acetyl]coenzyme A; (3R,5S,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18,21-dithia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide; TGC
Indication
Disease Entry ICD 11 Status REF
Arthritis FA20 Phase 3 [1]
Cross-matching ID
PubChem CID
24768536
TTD Drug ID
DMLCXPD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Transforming growth factor beta 1 (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [3]
A435 DMJCL7X Aggressive cancer 2A00-2F9Z IND submitted [4]
LY2157299 DMP8HW1 Arteriosclerosis BD40 Phase 2/3 [5]
Disitertide DM2QBDS Macular degeneration 9B78.3 Phase 2 [6]
SRK-181 DM0EWMT Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
ABBV-151 DMIQXDJ Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
ACE-1334 DMF1OUP Systemic sclerosis 4A42 Phase 1 [9]
Mannose phosphate DM1LM7D Lesion 8A00-8C12 Discontinued in Phase 2 [10]
ART-144 DMEVT4I Osteoarthritis FA00-FA05 Investigative [11]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transforming growth factor beta 1 (TGFB1) TTR9XHZ TGFB1_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT02072070) Efficacy and Safety Study of TissueGene-C to Degenerative Arthritis. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Tissue Gene, Inc.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Clinical pipeline report, company report or official report of Klus Pharma
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Perspectives of TGF-beta inhibition in pancreatic and hepatocellular carcinomas. Oncotarget. 2014 January; 5(1): 78-94.
7 Clinical pipeline report, company report or official report of Scholar Rock.
8 Clinical pipeline report, company report or official report of AbbVie.
9 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
10 The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-beta1 pathway in human lung fibroblasts. Immunol Lett. 2015 Jun;165(2):90-101.
11 Pharmaceutical products of TORREYA partners. December 2011.