Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLDB1X)

Drug Name
Andecaliximab Drug Info
Indication
Disease Entry ICD 11 Status REF
Gastric adenocarcinoma 2B72 Phase 3 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Cross-matching ID
TTD Drug ID
DMLDB1X

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Matrix metalloproteinase-9 (MMP-9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [3]
DP-b99 DM97S10 Stroke 8B20 Phase 3 [4]
GS-5745 DMP8MDW Gastric adenocarcinoma 2B72 Phase 3 [5]
BLZ-100 DMFKA4G Glioma 2A00.0 Phase 1/2 [6]
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [7]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [8]
PMID29130358-Compound-Figure17(12) DMML4PA N. A. N. A. Patented [8]
PMID29130358-Compound-Figure17(10) DMVA15O N. A. N. A. Patented [8]
PMID29130358-Compound-SB-3CT DMC64XQ N. A. N. A. Patented [8]
PMID29130358-Compound-Figure17(11) DMSZA9L N. A. N. A. Patented [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-9 (MMP-9) TT6X50U MMP9_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT02545504) Andecaliximab With mFOLFOX6 as First Line Treatment for Advanced Gastric or Gastroesophageal Junction Adenocarcinoma (GAMMA-1). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: effect on matrix metalloprote... Bioorg Med Chem. 2009 Feb 1;17(3):1290-6.
4 DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity. PLoS One. 2014 Jun 11;9(6):e99789.
5 National Cancer Institute Drug Dictionary (drug id 747683).
6 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
7 Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol. 2001 Dec;28(6):620-5.
8 Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46.