Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLHVWP)

• Drug Name: 1,1,1-Trifluoro-7-phenylheptan-2-one Drug Info
• Synonyms: 1,1,1-Trifluoro-7-phenyl-heptan-2-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9878121
  TTD Drug ID: DMLHVWP

Molecule-Related Drug Atlas

Drug(s) Targeting Fatty acid amide hydrolase (FAAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[3]
Thiopental	DMGP8AX	Anaesthesia	9A78.6	Approved	[4]
JNJ-42165279	DM72GZO	Anxiety disorder	6B00-6B0Z	Phase 2	[5]
SSR411298	DMGTB2Q	Major depressive disorder	6A70.3	Phase 2	[6]
IW-6118	DMP42W1	Inflammation	1A00-CA43.1	Phase 2	[7]
PF-04457845	DMPRYU1	Liver disease	DB90-BD99	Phase 2	[8]
IPI-940	DMEIM5G	Pain	MG30-MG3Z	Phase 1	[9]
PMID29053063-Compound-11d	DMDRK68	N. A.	N. A.	Patented	[10]
Piperazine carbamic compound 1	DMZSYU4	N. A.	N. A.	Patented	[10]
Piperazine carbamic compound 2	DMMQ0ZO	N. A.	N. A.	Patented	[10]

Drug(s) Targeting Cytosolic phospholipase A2 (GIVA cPLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZPL521	DMPZE2G	Atopic dermatitis	EA80	Phase 1/2	[11]
EFIPLADIB	DMJ0A5U	Asthma	CA23	Terminated	[12]
ARACHIDONYL TRIFLUOROMETHYLKETONE	DMHL48F	Discovery agent	N.A.	Investigative	[13]
1,1,1-Trifluoro-8-phenyl-octan-2-one	DMYENI7	Discovery agent	N.A.	Investigative	[1]
AR-C70484XX	DMU3A57	Discovery agent	N.A.	Investigative	[14]
1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one	DM3JHVL	Discovery agent	N.A.	Investigative	[14]
AX-006	DMDWCY7	Discovery agent	N.A.	Investigative	[15]
N-(4-Ethoxybutyl)-2-oxohexadecanamide	DM012TN	Discovery agent	N.A.	Investigative	[16]
[3,4''']biflavone	DMHU4NS	Discovery agent	N.A.	Investigative	[17]
1,1,1-Trifluoro-6-(naphthalen-2-yl)hexan-2-one	DMZ2VE3	Discovery agent	N.A.	Investigative	[18]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cytosolic phospholipase A2 (GIVA cPLA2)	TTT1JVS	PA24A_HUMAN	Inhibitor	[1]
Fatty acid amide hydrolase (FAAH)	TTDP1UC	NOUNIPROTAC	Inhibitor	[2]

References

• [1] Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37.
• [2] Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56.
• [3] Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
• [4] The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Pharma & Vaccines. Product Development Pipeline. April 29 2009.
• [7] The Discovery and Development of Inhibitors of Fatty Acid Amide Hydrolase (FAAH). Bioorg Med Chem Lett. 2011 August 15; 21(16): 4674-4685.
• [8] Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS Med Chem Lett. 2011 Feb 10;2(2):91-96.
• [9] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1400).
• [10] A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351.
• [11] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [12] Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors. J Med Chem. 2009 Feb 26;52(4):1156-71.
• [13] 85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells. Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282(4):G586-97.
• [14] 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52.
• [15] 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. Bioorg Med Chem. 2009 Jul 1;17(13):4833-43.
• [16] Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69.
• [17] Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Bioorg Med Chem. 2007 Nov 15;15(22):7138-43.
• [18] Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10.