Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDP1UC)

• DTT Name: Fatty acid amide hydrolase (FAAH)
• Synonyms: Oleamidehydrolase; Anandamide amidohydrolase
• Gene Name: FAAH
• DTT Type: Successful target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T11754
• Function: Degradesbioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
• KEGG Pathway: Retrograde endocannabinoid signaling (hsa04723)

Molecular Interaction Atlas (MIA) of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[2]
Thiopental	DMGP8AX	Anaesthesia	9A78.6	Approved	[1]

5 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IW-6118	DMP42W1	Inflammation	1A00-CA43.1	Phase 2	[3]
JNJ-42165279	DM72GZO	Anxiety disorder	6B00-6B0Z	Phase 2	[4]
PF-04457845	DMPRYU1	Liver disease	DB90-BD99	Phase 2	[5]
SSR411298	DMGTB2Q	Major depressive disorder	6A70.3	Phase 2	[6]
IPI-940	DMEIM5G	Pain	MG30-MG3Z	Phase 1	[7]

72 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aryl urea derivative 1	DM0B9SP	N. A.	N. A.	Patented	[8]
Aryl urea derivative 2	DMQWJ12	N. A.	N. A.	Patented	[8]
Aryl urea derivative 3	DM1G7KI	N. A.	N. A.	Patented	[8]
Aryl urea derivative 4	DM0HOJW	N. A.	N. A.	Patented	[8]
Aryl urea derivative 5	DM54V1R	N. A.	N. A.	Patented	[8]
Azetidine urea derivative 1	DMH942E	N. A.	N. A.	Patented	[8]
Azetidine urea derivative 2	DMJY8XI	N. A.	N. A.	Patented	[8]
Azetidine urea derivative 3	DM48PIO	N. A.	N. A.	Patented	[8]
Azole derivative 1	DM76HXA	N. A.	N. A.	Patented	[8]
Azole derivative 2	DMOPNJ6	N. A.	N. A.	Patented	[8]
Azole derivative 3	DMN9KTJ	N. A.	N. A.	Patented	[8]
Azole derivative 4	DMOW01E	N. A.	N. A.	Patented	[8]
Azole derivative 5	DM36QM5	N. A.	N. A.	Patented	[8]
Benzoxazole derivative 1	DMY01FU	N. A.	N. A.	Patented	[8]
Benzyl pyrrolyloxoacetamide derivative 1	DMIAB94	N. A.	N. A.	Patented	[8]
Benzyl pyrrolyloxoacetamide derivative 2	DMHOLQF	N. A.	N. A.	Patented	[8]
Boronic acid derivative 1	DMMRXEQ	N. A.	N. A.	Patented	[8]
Boronic acid derivative 2	DMLJH5T	N. A.	N. A.	Patented	[8]
Boronic acid derivative 3	DMQ8X94	N. A.	N. A.	Patented	[8]
Boronic acid derivative 4	DMVIFXR	N. A.	N. A.	Patented	[8]
Boronic acid derivative 5	DMUCW9Y	N. A.	N. A.	Patented	[8]
Boronic acid derivative 6	DMLMV4O	N. A.	N. A.	Patented	[8]
Carbamate derivative 1	DMNDPEA	N. A.	N. A.	Patented	[8]
Carbamate derivative 10	DMP98CL	N. A.	N. A.	Patented	[9]
Carbamate derivative 16	DMPLZSE	N. A.	N. A.	Patented	[9]
Carbamate derivative 17	DMYSRPT	N. A.	N. A.	Patented	[9]
Carbamate derivative 3	DMO6NWD	N. A.	N. A.	Patented	[8]
Carbamate derivative 7	DMOPF9N	N. A.	N. A.	Patented	[8]
Carbamate derivative 8	DMEAO42	N. A.	N. A.	Patented	[8]
Carbamate derivative 9	DMW4B1U	N. A.	N. A.	Patented	[9]
Carbamide derivative 1	DMXQTPJ	N. A.	N. A.	Patented	[8]
Carbamide derivative 24	DMD6Y73	N. A.	N. A.	Patented	[9]
Carbamide derivative 25	DM8ONCL	N. A.	N. A.	Patented	[9]
Carbamide derivative 26	DMDU9XF	N. A.	N. A.	Patented	[9]
Enol carbamate derivative 1	DMNBAZH	N. A.	N. A.	Patented	[8]
Ethylaminopyrimidine derivative 1	DMTBG39	N. A.	N. A.	Patented	[8]
Heteroaryl-substituted urea derivative 1	DM2BM1L	N. A.	N. A.	Patented	[8]
Heteroaryl-substituted urea derivative 2	DMHFQLC	N. A.	N. A.	Patented	[8]
Imidazolyl urea derivative 1	DM847I2	N. A.	N. A.	Patented	[8]
Isoxazoline derivative 1	DMLR8MS	N. A.	N. A.	Patented	[8]
Isoxazoline derivative 2	DMK5M8Q	N. A.	N. A.	Patented	[8]
Isoxazoline derivative 3	DMBVDHK	N. A.	N. A.	Patented	[8]
Isoxazoline derivative 4	DM01DG4	N. A.	N. A.	Patented	[8]
Ketoheterocycle derivative 1	DM1ZK7E	N. A.	N. A.	Patented	[8]
Ketoheterocycle derivative 2	DM3KW2A	N. A.	N. A.	Patented	[8]
Ketoheterocycle derivative 3	DMFHD05	N. A.	N. A.	Patented	[8]
Ketoheterocycle derivative 4	DM2LQXY	N. A.	N. A.	Patented	[8]
N-alkyl-4-oxazolecar boxamide derivative 1	DMU2WGL	N. A.	N. A.	Patented	[8]
N-alkyl-4-oxazolecar boxamide derivative 2	DMR6YAD	N. A.	N. A.	Patented	[8]
Piperazine carbamic compound 1	DMZSYU4	N. A.	N. A.	Patented	[9]
Piperazine carbamic compound 2	DMMQ0ZO	N. A.	N. A.	Patented	[9]
Piperazine urea derivative 1	DMEWAQ9	N. A.	N. A.	Patented	[8]
PMID26413912-Compound-84	DMNOJGW	N. A.	N. A.	Patented	[8]
PMID29053063-Compound-11d	DMDRK68	N. A.	N. A.	Patented	[9]
PMID29053063-Compound-14	DMBR72X	N. A.	N. A.	Patented	[9]
PMID29053063-Compound-15	DM07U5R	N. A.	N. A.	Patented	[9]
Pyrazole derivative 80	DMQ3TGM	N. A.	N. A.	Patented	[9]
Pyrazole derivative 81	DMWT437	N. A.	N. A.	Patented	[9]
Pyrazole derivative 82	DMETCI3	N. A.	N. A.	Patented	[9]
Pyrazole derivative 83	DMMGLOA	N. A.	N. A.	Patented	[9]
Pyrazole derivative 84	DME8Q0F	N. A.	N. A.	Patented	[9]
Pyrimidinyl ethylenediamine derivative 1	DMZ83P1	N. A.	N. A.	Patented	[8]
Pyrrolidinyl urea derivative 1	DM7DF6Z	N. A.	N. A.	Patented	[8]
Spirocyclic diamine urea derivative 1	DM4R7OQ	N. A.	N. A.	Patented	[8]
Spirocyclic diamine urea derivative 2	DMH5N78	N. A.	N. A.	Patented	[8]
Tetra-hydro-naphthalene derivative 1	DMURYO0	N. A.	N. A.	Patented	[8]
Tetra-hydro-naphthalene derivative 2	DMEBGZJ	N. A.	N. A.	Patented	[8]
Tetra-hydro-naphthalene derivative 3	DMVBZKF	N. A.	N. A.	Patented	[8]
Tetra-hydro-naphthyridine derivative 1	DM5YSTU	N. A.	N. A.	Patented	[8]
Tetra-substituted urea derivative 1	DMEG5YO	N. A.	N. A.	Patented	[8]
Tetra-substituted urea derivative 2	DMKXZUA	N. A.	N. A.	Patented	[8]
Tetrazolyl urea derivative 1	DM2D4WQ	N. A.	N. A.	Patented	[8]

220 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+/-)-3-(but-3-enyl)-1-pent-4-enoylazetidin-2-one	DM9AJSU	Discovery agent	N.A.	Investigative	[10]
(+/-)-3-(pent-4-enyl)azetidin-2-one	DMWIABE	Discovery agent	N.A.	Investigative	[10]
(+/-)-3-allyl-1-pent-4-enoylazetidin-2-one	DMS5AWP	Discovery agent	N.A.	Investigative	[10]
(+/-)-3-allylazetidin-2-one	DMK42RU	Discovery agent	N.A.	Investigative	[10]
(+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate	DM8023E	Discovery agent	N.A.	Investigative	[11]
(+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate	DMI5R3E	Discovery agent	N.A.	Investigative	[11]
(Z)-1,1,1-Trifluoro-nonadec-10-en-2-one	DMBTMDG	Discovery agent	N.A.	Investigative	[12]
(Z)-1-(4-phenyloxazol-2-yl)octadec-9-en-1-one	DMVZYNH	Discovery agent	N.A.	Investigative	[13]
(Z)-1-(benzo[d]oxazol-2-yl)octadec-9-en-1-one	DMNBDGH	Discovery agent	N.A.	Investigative	[13]
(Z)-1-(pyridazin-3-yl)octadec-9-en-1-one	DMMTXKO	Discovery agent	N.A.	Investigative	[13]
(Z)-2,2-Dimethyl-1-oxazol-2-yl-octadec-9-en-1-one	DM2HZX8	Discovery agent	N.A.	Investigative	[14]
(Z)-2-Methyl-1-oxazol-2-yl-octadec-9-en-1-one	DMYH9BC	Discovery agent	N.A.	Investigative	[14]
1,1,1-trifluoro-3-(hexylthio)propan-2-one	DMWGSP6	Discovery agent	N.A.	Investigative	[15]
1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one	DMLBT0E	Discovery agent	N.A.	Investigative	[15]
1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one	DMT29SN	Discovery agent	N.A.	Investigative	[15]
1,1,1-trifluoro-3-(octylthio)propan-2-one	DMU4EJW	Discovery agent	N.A.	Investigative	[15]
1,1,1-Trifluoro-7-phenylheptan-2-one	DMLHVWP	Discovery agent	N.A.	Investigative	[12]
1,1,1-Trifluoro-8-phenyl-octan-2-one	DMYENI7	Discovery agent	N.A.	Investigative	[12]
1,1,1-Trifluoro-9-phenyl-nonan-2-one	DM7DWVL	Discovery agent	N.A.	Investigative	[12]
1,1,1-Trifluoro-nonadecan-2-one	DM8TWY7	Discovery agent	N.A.	Investigative	[12]
1,1,1-Trifluoro-tridecan-2-one	DM4CEQP	Discovery agent	N.A.	Investigative	[12]
1,1,1-Trifluoro-undecan-2-one	DMX2SFW	Discovery agent	N.A.	Investigative	[12]
1,1,1-trifluorododecan-2-one	DMW6CQV	Discovery agent	N.A.	Investigative	[15]
1,10-(methylenedi-4,1-phenylene)bismaleimide	DMYVBD2	Discovery agent	N.A.	Investigative	[16]
1,4-bis(malimido)xylene	DMC4LMT	Discovery agent	N.A.	Investigative	[16]
1,8-bis-maleimidodiethyleneglycol	DMKJGTH	Discovery agent	N.A.	Investigative	[16]
1-(1,2,4-Oxadiazol-3-yl)-7-phenylheptan-1-one	DMPMLZF	Discovery agent	N.A.	Investigative	[17]
1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one	DMBS90M	Discovery agent	N.A.	Investigative	[17]
1-(1,3,4-Oxadiazol-2-yl)-7-phenylheptan-1-one	DMHIYB3	Discovery agent	N.A.	Investigative	[17]
1-(1,3,4-oxadiazol-2-yl)octadec-9-en-1-one	DMZ1GH0	Discovery agent	N.A.	Investigative	[17]
1-(1,3,4-thiadiazol-2-yl)octadec-9-en-1-one	DM6B14Q	Discovery agent	N.A.	Investigative	[17]
1-(4-acetyloxazol-2-yl)-7-phenylheptan-1-one	DM170BV	Discovery agent	N.A.	Investigative	[18]
1-(4-bromooxazol-2-yl)-7-phenylheptan-1-one	DMUMNYZ	Discovery agent	N.A.	Investigative	[18]
1-(4-chlorooxazol-2-yl)-7-phenylheptan-1-one	DMXGB38	Discovery agent	N.A.	Investigative	[18]
1-(4-iodooxazol-2-yl)-7-phenylheptan-1-one	DMDY93H	Discovery agent	N.A.	Investigative	[18]
1-(4-methoxyoxazol-2-yl)-7-phenylheptan-1-one	DMEPJRD	Discovery agent	N.A.	Investigative	[18]
1-(4-methyloxazol-2-yl)-7-phenylheptan-1-one	DMVI2PM	Discovery agent	N.A.	Investigative	[18]
1-(5-(furan-2-yl)oxazol-2-yl)octadec-9-en-1-one	DMPL3UZ	Discovery agent	N.A.	Investigative	[17]
1-(5-(pyridin-2-yl)oxazol-2-yl)dodecan-1-one	DM4V9IB	Discovery agent	N.A.	Investigative	[13]
1-(5-(pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one	DMICZK0	Discovery agent	N.A.	Investigative	[17]
1-(5-(pyridin-2-yl)oxazol-2-yl)octan-1-one	DMZNEIB	Discovery agent	N.A.	Investigative	[13]
1-(5-(pyridin-2-yl)oxazol-2-yl)pentan-1-one	DM6FDAY	Discovery agent	N.A.	Investigative	[13]
1-(5-fluorooxazol-2-yl)-7-phenylheptan-1-one	DMD8IYZ	Discovery agent	N.A.	Investigative	[13]
1-(5-methyloxazol-2-yl)-7-phenylheptan-1-one	DMWQ9ZP	Discovery agent	N.A.	Investigative	[13]
1-(5-phenyloxazol-2-yl)octadec-9-en-1-one	DMRITHA	Discovery agent	N.A.	Investigative	[17]
1-(5-Pyridin-2-yl-oxazol-2-yl)-octadec-9-yn-1-one	DM4IMON	Discovery agent	N.A.	Investigative	[12]
1-(oxazol-2-yl)-3-(4-phenoxyphenyl)propan-1-one	DMXT2ZL	Discovery agent	N.A.	Investigative	[19]
1-(oxazol-2-yl)-4-(piperidin-4-yl)butan-1-one	DMEOS8P	Discovery agent	N.A.	Investigative	[20]
1-(oxazol-2-yl)-7-phenylheptan-1-one	DMLKA5O	Discovery agent	N.A.	Investigative	[18]
1-(oxazol-2-yl)octadec-9-en-1-one	DM1ATS3	Discovery agent	N.A.	Investigative	[17]
1-(oxazolo[4,5-b]pyridin-2-yl)dodecan-1-one	DMT7P2Z	Discovery agent	N.A.	Investigative	[13]
1-(oxazolo[4,5-b]pyridin-2-yl)octan-1-one	DMFGUXZ	Discovery agent	N.A.	Investigative	[13]
1-(oxazolo[4,5-b]pyridin-2-yl)pentan-1-one	DMH2G13	Discovery agent	N.A.	Investigative	[13]
1-Benzooxazol-2-yl-6-phenyl-hexan-1-one	DM153Y8	Discovery agent	N.A.	Investigative	[12]
1-Biphenyl-4-ylmaleimide	DM9QTWB	Discovery agent	N.A.	Investigative	[16]
1-Biphenyl-4-ylmethylmaleimide	DMKL201	Discovery agent	N.A.	Investigative	[16]
1-DODECANOL	DM7P3N5	Discovery agent	N.A.	Investigative	[21]
1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one	DM3JHVL	Discovery agent	N.A.	Investigative	[22]
1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one	DMPMGLO	Discovery agent	N.A.	Investigative	[23]
1-Oxazolo[4,5-b]pyridin-2-yl-octadec-9-yn-1-one	DM9BY8D	Discovery agent	N.A.	Investigative	[12]
2,2-dimethyl-3-methyleneheptadecane	DM7BL04	Discovery agent	N.A.	Investigative	[15]
2,4-difluorophenyl 4-butoxybenzylcarbamate	DM75TJ1	Discovery agent	N.A.	Investigative	[24]
2-(7-phenylheptanoyl)oxazole-4-carbaldehyde	DMJAEZ8	Discovery agent	N.A.	Investigative	[18]
2-(7-phenylheptanoyl)oxazole-4-carbonitrile	DMVSL49	Discovery agent	N.A.	Investigative	[18]
2-(7-phenylheptanoyl)oxazole-4-carboxamide	DM9JMF2	Discovery agent	N.A.	Investigative	[18]
2-(7-phenylheptanoyl)oxazole-4-carboxylic acid	DM9BE2S	Discovery agent	N.A.	Investigative	[18]
2-(7-phenylheptanoyl)oxazole-5-carbonitrile	DM89RYN	Discovery agent	N.A.	Investigative	[18]
2-(7-phenylheptanoyl)oxazole-5-carboxylic acid	DMB53ML	Discovery agent	N.A.	Investigative	[18]
2-(biphenyl-4-yl)vinylboronic acid	DMRQOKB	Discovery agent	N.A.	Investigative	[25]
2-arachidonoylglycerol	DMM0KOJ	Discovery agent	N.A.	Investigative	[26]
2-chloro-1-(5-(pyridin-2-yl)oxazol-2-yl)ethanone	DMG5SAQ	Discovery agent	N.A.	Investigative	[27]
2-Cyclohexylacetic acidbiphenyl-3-yl ester	DMS1T0V	Discovery agent	N.A.	Investigative	[28]
2-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate	DM5OW91	Discovery agent	N.A.	Investigative	[24]
2-fluorophenyl 4'-ethylbiphenyl-4-ylcarbamate	DMGIKWA	Discovery agent	N.A.	Investigative	[24]
2-fluorophenyl 4-(decyloxy)phenylcarbamate	DMSFQAZ	Discovery agent	N.A.	Investigative	[24]
2-fluorophenyl 4-(dodecyloxy)phenylcarbamate	DMCEGZU	Discovery agent	N.A.	Investigative	[24]
2-fluorophenyl 4-(heptyloxy)phenylcarbamate	DMLM2WU	Discovery agent	N.A.	Investigative	[24]
2-fluorophenyl 4-(hexyloxy)phenylcarbamate	DM854ED	Discovery agent	N.A.	Investigative	[24]
2-fluorophenyl 4-(octyloxy)phenylcarbamate	DM81J0O	Discovery agent	N.A.	Investigative	[24]
2-fluorophenyl 4-(undecyloxy)phenylcarbamate	DMTYX5G	Discovery agent	N.A.	Investigative	[24]
2-fluorophenyl 4-butoxybenzylcarbamate	DM4EIQ3	Discovery agent	N.A.	Investigative	[24]
2-fluorophenyl 4-butoxyphenylcarbamate	DMYJ1M4	Discovery agent	N.A.	Investigative	[24]
2-fluorophenyl 4-phenoxyphenylcarbamate	DMSMDQC	Discovery agent	N.A.	Investigative	[24]
2-fluorophenylboronic acid	DMXPFYZ	Discovery agent	N.A.	Investigative	[25]
2-methoxyphenylboronic acid	DML5PE9	Discovery agent	N.A.	Investigative	[25]
3'-carbamoylbiphenyl-3-yl 6-phenylhexylcarbamate	DM530OW	Discovery agent	N.A.	Investigative	[29]
3,3-di(pent-4-enyl)azetidin-2-one	DMK9BN0	Discovery agent	N.A.	Investigative	[10]
3-(4,5-Dihydrooxazol-2-yl)phenyl propylcarbamate	DMONSM1	Discovery agent	N.A.	Investigative	[30]
3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate	DMPFH8U	Discovery agent	N.A.	Investigative	[30]
3-(biphenyl-4-yl)-1-(oxazol-2-yl)propan-1-one	DM4GWJO	Discovery agent	N.A.	Investigative	[19]
3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one	DMWJ6UD	Discovery agent	N.A.	Investigative	[15]
3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one	DMF27YT	Discovery agent	N.A.	Investigative	[15]
3-(decylthio)-1,1,1-trifluoropropan-2-one	DM1Y6L8	Discovery agent	N.A.	Investigative	[15]
3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one	DM7AG6Y	Discovery agent	N.A.	Investigative	[15]
3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one	DMPRCS0	Discovery agent	N.A.	Investigative	[15]
3-(ethoxycarbonyl)phenylboronic acid	DM71EMN	Discovery agent	N.A.	Investigative	[25]
3-(trifluoromethyl)phenyl 4-butoxybenzylcarbamate	DMH7K0N	Discovery agent	N.A.	Investigative	[24]
3-(trifluoromethyl)phenylboronic acid	DM4B5JY	Discovery agent	N.A.	Investigative	[25]
3-chlorophenyl 4-butoxybenzylcarbamate	DMJ2SZ1	Discovery agent	N.A.	Investigative	[24]
3-cyanophenylboronic acid	DMPWR90	Discovery agent	N.A.	Investigative	[25]
3-methoxyphenylboronic acid	DMHJTLW	Discovery agent	N.A.	Investigative	[25]
4-(1,2,3-thiadiazol-4-yl)phenyl butylcarbamate	DMG4HO3	Discovery agent	N.A.	Investigative	[31]
4-(1,2,3-thiadiazol-4-yl)phenyl hexylcarbamate	DMSFGRI	Discovery agent	N.A.	Investigative	[31]
4-(4,5-dihydrothiazol-2-yl)phenyl butylcarbamate	DMOF0J1	Discovery agent	N.A.	Investigative	[31]
4-(cyclohexylmethylcarbamoyloxy)benzoic acid	DMWYESB	Discovery agent	N.A.	Investigative	[29]
4-(thiazol-2-yl)phenyl butylcarbamate	DMSUM3C	Discovery agent	N.A.	Investigative	[32]
4-(trifluoromethyl)phenylboronic acid	DMADZQ9	Discovery agent	N.A.	Investigative	[25]
4-cyanophenyl ethyl dodecylphosphonate	DMEP80Q	Discovery agent	N.A.	Investigative	[33]
4-cyanophenylboronic acid	DMOLFHZ	Discovery agent	N.A.	Investigative	[25]
4-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate	DMZV3MD	Discovery agent	N.A.	Investigative	[24]
4-fluorophenyl 4-butoxybenzylcarbamate	DMCRJ54	Discovery agent	N.A.	Investigative	[24]
4-fluorophenylboronic acid	DMD5LXQ	Discovery agent	N.A.	Investigative	[25]
4-methoxyphenyl 1-(4-butoxyphenyl)propylcarbamate	DM739SQ	Discovery agent	N.A.	Investigative	[24]
4-methoxyphenylboronic acid	DMP5YFQ	Discovery agent	N.A.	Investigative	[25]
4-Nitrophenyl 4-Benzylpiperazine-1-carboxylate	DMTJ3F9	Discovery agent	N.A.	Investigative	[34]
4-nitrophenylboronic acid	DMO6XK2	Discovery agent	N.A.	Investigative	[25]
4-nonylphenylboronic acid	DMBF5KW	Discovery agent	N.A.	Investigative	[25]
4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester	DM871ZE	Discovery agent	N.A.	Investigative	[28]
6-fluoropyridin-3-ylboronic acid	DMS325C	Discovery agent	N.A.	Investigative	[25]
6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester	DMLJN8Z	Discovery agent	N.A.	Investigative	[28]
7-Phenyl-1-(1,3,4-thiadiazol-2-yl)-heptan-1-one	DMQMRGD	Discovery agent	N.A.	Investigative	[17]
7-Phenyl-1-(2H-tetrazol-5-yl)-heptan-1-one	DMEABGI	Discovery agent	N.A.	Investigative	[17]
7-phenyl-1-(4-phenyloxazol-2-yl)heptan-1-one	DM62PAU	Discovery agent	N.A.	Investigative	[18]
7-phenyl-1-(5-phenyloxazol-2-yl)heptan-1-one	DM9SGBW	Discovery agent	N.A.	Investigative	[17]
7-Phenyl-1-(pyridazin-3-yl)-heptan-1-one	DMG1PNX	Discovery agent	N.A.	Investigative	[17]
7-Phenyl-1-(thiazol-2-yl)-heptan-1-one	DMLHI5T	Discovery agent	N.A.	Investigative	[17]
8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester	DM4TWRJ	Discovery agent	N.A.	Investigative	[28]
Adamant-1-ylcarbamic Acid Biphenyl-3-yl Ester	DMKDRVZ	Discovery agent	N.A.	Investigative	[28]
Allylcarbamic Acid Biphenyl-3-yl Ester	DMJWZB3	Discovery agent	N.A.	Investigative	[28]
AM-404	DMBK9PS	Discovery agent	N.A.	Investigative	[35]
AR-C70484XX	DMU3A57	Discovery agent	N.A.	Investigative	[22]
ARACHIDONYL TRIFLUOROMETHYLKETONE	DMHL48F	Discovery agent	N.A.	Investigative	[22]
Benzaldehyde O-4-(decyloxy)phenylcarbamoyl oxime	DMFPSOQ	Discovery agent	N.A.	Investigative	[24]
Benzaldehyde O-4-(heptyloxy)phenylcarbamoyl oxime	DMU7INH	Discovery agent	N.A.	Investigative	[24]
Benzaldehyde O-4-(hexyloxy)phenylcarbamoyl oxime	DMOK0U8	Discovery agent	N.A.	Investigative	[24]
Benzaldehyde O-4-(nonyloxy)phenylcarbamoyl oxime	DMIV3S8	Discovery agent	N.A.	Investigative	[24]
Benzaldehyde O-4-(octyloxy)phenylcarbamoyl oxime	DMBW7PX	Discovery agent	N.A.	Investigative	[24]
Benzaldehyde O-4-(pentyloxy)phenylcarbamoyl oxime	DMWEXOY	Discovery agent	N.A.	Investigative	[24]
Benzaldehyde O-4-butoxyphenylcarbamoyl oxime	DMHUQWN	Discovery agent	N.A.	Investigative	[24]
Benzaldehyde O-4-ethoxyphenylcarbamoyl oxime	DMD98YP	Discovery agent	N.A.	Investigative	[24]
Benzaldehyde O-4-methoxyphenylcarbamoyl oxime	DMLHKQS	Discovery agent	N.A.	Investigative	[24]
Benzaldehyde O-4-propoxyphenylcarbamoyl oxime	DMARBF9	Discovery agent	N.A.	Investigative	[24]
Benzofuran-2-ylboronic acid	DMQ7I06	Discovery agent	N.A.	Investigative	[25]
Benzo[b]thiophen-2-ylboronic acid	DMJQSLW	Discovery agent	N.A.	Investigative	[25]
Benzylcarbamic Acid Biphenyl-3-yl Ester	DM7M9O2	Discovery agent	N.A.	Investigative	[28]
Biphenyl-3-ylboronic acid	DMIAUB1	Discovery agent	N.A.	Investigative	[25]
Biphenyl-3-ylcarbamic Acid Biphenyl-3-yl Ester	DMYCKGH	Discovery agent	N.A.	Investigative	[28]
Biphenyl-3-ylcarbamic acid cyclohexyl ester	DM10AUP	Discovery agent	N.A.	Investigative	[16]
Biphenyl-4-ylboronic acid	DMIHMP5	Discovery agent	N.A.	Investigative	[25]
BMS-1	DM4D6ZB	Discovery agent	N.A.	Investigative	[36]
bromoenol lactone	DMKQ0CA	Discovery agent	N.A.	Investigative	[29]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[37]
Cyclobutylcarbamic Acid Biphenyl-3-yl Ester	DMYLA7F	Discovery agent	N.A.	Investigative	[28]
Cyclohexyl biphenyl-4-ylcarbamate	DMZKH4R	Discovery agent	N.A.	Investigative	[31]
Cyclohexylcarbamic acidbiphenyl-3-yl ester	DM06OLY	Discovery agent	N.A.	Investigative	[28]
Cyclohexylmethylcarbamic Acid Biphenyl-3-yl Ester	DMEW7AY	Discovery agent	N.A.	Investigative	[28]
Cyclopentyl(5-(pyridin-2-yl)oxazol-2-yl)methanone	DM0J9I5	Discovery agent	N.A.	Investigative	[27]
Cyclopentylcarbamic Acid Biphenyl-3-yl Ester	DMQLGFH	Discovery agent	N.A.	Investigative	[28]
Dodecane-1-sulfonyl fluoride	DME9CGK	Discovery agent	N.A.	Investigative	[33]
Ethyl octylfluorophosphonate	DMXMRK7	Discovery agent	N.A.	Investigative	[37]
Furan-2-ylmethylcarbamic Acid Biphenyl-3-yl Ester	DM9XPUN	Discovery agent	N.A.	Investigative	[28]
HTS-00798	DMXV379	Discovery agent	N.A.	Investigative	[32]
Indan-2-ylcarbamic Acid Biphenyl-3-yl Ester	DMVZMBU	Discovery agent	N.A.	Investigative	[28]
Isopropyl 4-nitrophenyl dodecylphosphonate	DM2VJF4	Discovery agent	N.A.	Investigative	[33]
Isopropyl dodecylfluorophosphonate	DML54EA	Discovery agent	N.A.	Investigative	[37]
Isopropylcarbamic Acid Biphenyl-3-yl Ester	DMBR8P1	Discovery agent	N.A.	Investigative	[28]
JNJ-1661010	DM3ZNF9	Discovery agent	N.A.	Investigative	[38]
LY-2183240	DM8SU6N	Discovery agent	N.A.	Investigative	[29]
LY-2318912	DMPV6N9	Discovery agent	N.A.	Investigative	[39]
Methoxy arachidonyl fluorophosphonate	DMX8QK0	Discovery agent	N.A.	Investigative	[40]
Methyl 2-(7-phenylheptanoyl)oxazole-4-carboxylate	DMP06I3	Discovery agent	N.A.	Investigative	[18]
Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate	DM9FA26	Discovery agent	N.A.	Investigative	[17]
Methyl icosylphosphonofluoridate	DM9O5S6	Discovery agent	N.A.	Investigative	[33]
Methylcarbamic Acid Biphenyl-3-yl Ester	DMDP84X	Discovery agent	N.A.	Investigative	[28]
N-(2-hydroxyethyl)linoleoylamide	DM97MGE	Discovery agent	N.A.	Investigative	[41]
N-(2-iodethyl)arachidonylamide	DM8ORQ4	Discovery agent	N.A.	Investigative	[41]
N-(2-iodoethyl)linoleoylamide	DMV84PQ	Discovery agent	N.A.	Investigative	[41]
N-(4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide	DM7O5WS	Discovery agent	N.A.	Investigative	[35]
N-arachidonylmaleimide	DMLVGT8	Discovery agent	N.A.	Investigative	[16]
N-Butylcarbamic Acid Biphenyl-3-yl Ester	DMW7BZT	Discovery agent	N.A.	Investigative	[28]
N-Hexylcarbamic Acid Biphenyl-3-yl Ester	DML27CG	Discovery agent	N.A.	Investigative	[28]
N-Octylcarbamic Acid Biphenyl-3-yl Ester	DM95JEW	Discovery agent	N.A.	Investigative	[28]
Naphthalen-2-yl cyclohexylcarbamate	DMDXM2A	Discovery agent	N.A.	Investigative	[29]
NICARBAZIN	DM4I6MD	Discovery agent	N.A.	Investigative	[42]
Nicotinaldehyde O-4-butoxyphenylcarbamoyl oxime	DM0DFNJ	Discovery agent	N.A.	Investigative	[24]
Nicotinaldehyde O-4-ethoxyphenylcarbamoyl oxime	DM957CK	Discovery agent	N.A.	Investigative	[24]
Nicotinaldehyde O-4-propoxyphenylcarbamoyl oxime	DMC9WAL	Discovery agent	N.A.	Investigative	[24]
Octane-1-sulfonyl fluoride	DMDBI5S	Discovery agent	N.A.	Investigative	[33]
OL-135	DMT1CZ0	Pain	MG30-MG3Z	Investigative	[43]
OL-92	DM5ZJ3G	Discovery agent	N.A.	Investigative	[36]
Org-231295	DMTFGYH	Anxiety disorder	6B00-6B0Z	Investigative	[7]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[37]
PF3845	DMCRXAM	Discovery agent	N.A.	Investigative	[44]
PF750	DMBE24Y	Discovery agent	N.A.	Investigative	[45]
Phenethylboronic acid	DMPDVG2	Discovery agent	N.A.	Investigative	[25]
Phenethylcarbamic Acid Biphenyl-3-yl Ester	DM02PAW	Discovery agent	N.A.	Investigative	[28]
PHENMEDIPHAM	DMYCHTD	Discovery agent	N.A.	Investigative	[42]
Phenyl 1-(4-butoxyphenyl)propylcarbamate	DMSNIBO	Discovery agent	N.A.	Investigative	[24]
Phenyl 4-(decyloxy)phenylcarbamate	DMZ03DT	Discovery agent	N.A.	Investigative	[24]
Phenyl 4-(dodecyloxy)phenylcarbamate	DMR1MQE	Discovery agent	N.A.	Investigative	[24]
Phenyl 4-(heptyloxy)phenylcarbamate	DM9UNLH	Discovery agent	N.A.	Investigative	[24]
Phenyl 4-(hexyloxy)phenylcarbamate	DMZ07H6	Discovery agent	N.A.	Investigative	[24]
Phenyl 4-(octyloxy)phenylcarbamate	DMULMWK	Discovery agent	N.A.	Investigative	[24]
Phenyl 4-(undecyloxy)phenylcarbamate	DMSZ2CO	Discovery agent	N.A.	Investigative	[24]
Phenyl Boronic acid	DMFZH49	Discovery agent	N.A.	Investigative	[25]
Phenyl-1,4-bismaleimide	DMWEKBD	Discovery agent	N.A.	Investigative	[16]
Phenylcarbamic Acid Biphenyl-3-yl Ester	DMMNYXK	Discovery agent	N.A.	Investigative	[28]
Propan-2-one O-3-butoxyphenylcarbamoyl oxime	DMQZYW6	Discovery agent	N.A.	Investigative	[24]
Propan-2-one O-4-(decyloxy)phenylcarbamoyl oxime	DMIQ0DF	Discovery agent	N.A.	Investigative	[24]
Propan-2-one O-4-(heptyloxy)phenylcarbamoyl oxime	DM8FXM6	Discovery agent	N.A.	Investigative	[24]
Propan-2-one O-4-(hexyloxy)phenylcarbamoyl oxime	DM5J0H3	Discovery agent	N.A.	Investigative	[24]
Propan-2-one O-4-(nonyloxy)phenylcarbamoyl oxime	DMYBH91	Discovery agent	N.A.	Investigative	[24]
Propan-2-one O-4-(octyloxy)phenylcarbamoyl oxime	DM6VZ4S	Discovery agent	N.A.	Investigative	[24]
Propan-2-one O-4-(pentyloxy)phenylcarbamoyl oxime	DM408U3	Discovery agent	N.A.	Investigative	[24]
Propan-2-one O-4-butoxybenzylcarbamoyl oxime	DMV13MO	Discovery agent	N.A.	Investigative	[24]
Propan-2-one O-4-butoxyphenylcarbamoyl oxime	DMYJ28G	Discovery agent	N.A.	Investigative	[24]
Propan-2-one O-4-ethoxyphenylcarbamoyl oxime	DM573UT	Discovery agent	N.A.	Investigative	[24]
Propan-2-one O-4-propoxyphenylcarbamoyl oxime	DMWX5Q6	Discovery agent	N.A.	Investigative	[24]
Pyridin-3-yl 4-butoxybenzylcarbamate	DMOCG6M	Discovery agent	N.A.	Investigative	[24]
VER-156084	DMFZMA2	Neuropathic pain	8E43.0	Investigative	[46]

Molecular Expression Atlas (MEA) of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Major depressive disorder	6A20	Pre-frontal cortex	2.65E-01	0.02	0.1

References

• [1] The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13.
• [2] Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
• [3] The Discovery and Development of Inhibitors of Fatty Acid Amide Hydrolase (FAAH). Bioorg Med Chem Lett. 2011 August 15; 21(16): 4674-4685.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS Med Chem Lett. 2011 Feb 10;2(2):91-96.
• [6] Pharma & Vaccines. Product Development Pipeline. April 29 2009.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1400).
• [8] Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66.
• [9] A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351.
• [10] 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4163-7.
• [11] Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. J Med Chem. 2007 Oct 4;50(20):5012-23.
• [12] Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56.
• [13] Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95.
• [14] alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1517-20.
• [15] Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30.
• [16] Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 Dec 10;52(23):7410-20.
• [17] Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403.
• [18] Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6.
• [19] Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Feb 28;51(4):937-47.
• [20] Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH). Bioorg Med Chem Lett. 2008 Mar 15;18(6):2109-13.
• [21] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [22] 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52.
• [23] The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem. 2005 Aug 11;48(16):5059-87.
• [24] Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7.
• [25] Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60.
• [26] Conformationally constrained analogues of 2-arachidonoylglycerol. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5959-63.
• [27] Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem. 2007 Jul 12;50(14):3359-68.
• [28] Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98.
• [29] Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. J Med Chem. 2008 Dec 11;51(23):7327-43.
• [30] Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and int... Eur J Med Chem. 2009 Oct;44(10):4179-91.
• [31] The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors. Eur J Med Chem. 2009 Jul;44(7):2994-3008.
• [32] Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. J Med Chem. 2006 Jul 27;49(15):4650-6.
• [33] Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8.
• [34] Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem. 2010 Feb 25;53(4):1830-42.
• [35] New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5.
• [36] Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors. J Med Chem. 2009 Jan 8;52(1):170-80.
• [37] Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8.
• [38] Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43.
• [39] Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. Eur J Med Chem. 2008 Jan;43(1):62-72.
• [40] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [41] Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. Bioorg Med Chem. 2009 Jan 1;17(1):49-56.
• [42] Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inh... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6793-6.
• [43] X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J Med Chem. 2010 Jan 14;53(1):230-40.
• [44] Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol. 2009 Apr 24;16(4):411-20.
• [45] Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. 2007 Nov 13;46(45):13019-30.
• [46] Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4.