Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLI2DZ)

Drug Name
Pegzilarginase Drug Info
Indication
Disease Entry ICD 11 Status REF
Arginase 1 deficiency 5C50.A2 Phase 3 [1]
Cross-matching ID
TTD Drug ID
DMLI2DZ

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arginase-1 (ARG1) TT7ZQEV ARGI1_HUMAN Replacement [2]

References

1 ClinicalTrials.gov (NCT03921541) Efficacy and Safety of Pegzilarginase in Patients With Arginase 1 Deficiency. U.S. National Institutes of Health.
2 Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a PEGylated, cobalt-substituted recombinant human arginase 1. Transl Res. 2020 Mar;217:11-22.