Details of the Drug

General Information of Drug (ID: DMLI2DZ)

Drug Name
Pegzilarginase
Indication
Disease Entry ICD 11 Status REF
Arginase 1 deficiency 5C50.A2 Phase 3 [1]
Drug Type
Enzyme replacement
Cross-matching ID
TTD ID
DX2H9P

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arginase-1 (ARG1) TT7ZQEV ARGI1_HUMAN Replacement [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT03921541) Efficacy and Safety of Pegzilarginase in Patients With Arginase 1 Deficiency. U.S. National Institutes of Health.
2 Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a PEGylated, cobalt-substituted recombinant human arginase 1. Transl Res. 2020 Mar;217:11-22.