General Information of Drug (ID: DMLO2QY)

Drug Name
Z-321 Drug Info
Synonyms 1-[3-(2-Indanylacetyl)thiazolidin-4(R)-ylcarbonyl]pyrrolidine; 1-[N-(2-Indanylacetyl)-4-thia-L-prolyl]pyrrolidine
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Discontinued in Phase 1 [1]
Cross-matching ID
PubChem CID
9798234
CAS Number
CAS 130849-58-0
TTD Drug ID
DMLO2QY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Prolyl endopeptidase (PREP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [3]
ALV-003 DMXSFA0 Coeliac disease DA95 Phase 2 [4]
ONO-1603 DMKIZAL Cognitive impairment 6D71 Phase 2 [5]
S-17092-1 DMYR1K8 Cognitive impairment 6D71 Phase 1 [6]
JTP-4819 DMI0UJS Cognitive impairment 6D71 Discontinued in Phase 2 [7]
BAICALIN DMY1TLZ Human immunodeficiency virus infection 1C62 Terminated [8]
Y-29794 DMLAVES N. A. N. A. Terminated [8]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [9]
Monothioglycerol DMENSOZ Discovery agent N.A. Investigative [9]
Z-Pro-Prolinal DM43O2U Discovery agent N.A. Investigative [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prolyl endopeptidase (PREP) TTNGKET PPCE_HUMAN Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003089)
2 Z-321, a prolyl endopeptidase inhibitor, augments the potentiation of synaptic transmission in rat hippocampal slices. Behav Brain Res. 1997 Feb;83(1-2):213-6.
3 Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg Med Chem. 2008 Aug 1;16(15):7516-24.
4 The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo. Clin Immunol. 2010 Mar;134(3):289-95.
5 ONO-1603, a potential antidementia drug, shows neuroprotective effects and increases m3-muscarinic receptor mRNA levels in differentiating rat cerebellar granule neurons. Neurosci Lett. 1996 Aug 23;214(2-3):151-4.
6 Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain. J Neurochem. 2003 Mar;84(5):919-29.
7 A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease. Behav Brain Res. 1997 Feb;83(1-2):147-51.
8 Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. J Med Chem. 2010 May 13;53(9):3423-38.
9 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
10 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.