Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLUA2J)

Drug Name

Nitroprusside Drug Info

Synonyms

Nitropress (TN); Nitroprusside sodium; Sodium nitroprusside (USP); Tox21_110314; Tox21_110314_1; 13755-38-9; 7304AF; A-8282; C07695; NITROPRUSSIDE SODIUM DIHYDRATE; C5FeN6O.2Na.2H2O; CAS-13755-38-9; CHEBI:9179; D00614; DSSTox_CID_21126; DSSTox_GSID_41126; DSSTox_RID_79630; DTXSID7041126; MFCD00149192; NCGC00166055-03; Na2[Fe(CN)5(NO)].2H2O; Sodium nitroferricyanide dihydrate, 99+%; Sodium nitroferricyanide dihydrate, reagent ACS; Sodium nitroferricyanide(III) dihydrate; Sodium nitroprusside hydrate (JAN)

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1]
Malignant essential hypertension	BA00	Approved	[2]
Sarcopenia	FB32.Y	Approved	[2]

Cross-matching ID

PubChem CID: 11953895
ChEBI ID: CHEBI:9179
CAS Number: CAS 13755-38-9
TTD Drug ID: DMLUA2J
INTEDE Drug ID: DR2825

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Inositol 1,4,5-trisphosphate receptor (ITPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-myo-inositol 1,4,5-trisphosphate	DMNUKIX	Discovery agent	N.A.	Investigative	[5]
ADENOPHOSTIN A	DMV39AW	Discovery agent	N.A.	Investigative	[6]
5'-Deoxy-5'-phenyladenophostin A	DMU4MCK	Discovery agent	N.A.	Investigative	[6]
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Drug(s) Metabolized By S-(hydroxymethyl)glutathione dehydrogenase (adh)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrosoglutathione	DMZ9WI4	N. A.	N. A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inositol 1,4,5-trisphosphate receptor (ITPR)	TTC9IZL	ITPR1_HUMAN; ITPR2_HUMAN; ITPR3_HUMAN	Antagonist	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
S-(hydroxymethyl)glutathione dehydrogenase (adh)^{Main DME}	DEAH3PE	A0A0A7DS01_VIBCL	Substrate	[4]

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References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 073465.
2	Nitroprusside FDA Label
3	Prostacyclin and sodium nitroprusside inhibit the activity of the platelet inositol 1,4,5-trisphosphate receptor and promote its phosphorylation. J Biol Chem. 1996 Mar 8;271(10):5545-51.
4	Nitrosative stress response in Vibrio cholerae: role of S-nitrosoglutathione reductase. Appl Biochem Biotechnol. 2017 Jul;182(3):871-884.
5	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
6	Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands. J Med Chem. 2006 Sep 21;49(19):5750-8.