Details of the Drug

General Information of Drug (ID: DMLUA2J)

• Drug Name: Nitroprusside
• Synonyms: Nitropress (TN); Nitroprusside sodium; Sodium nitroprusside (USP); Tox21_110314; Tox21_110314_1; 13755-38-9; 7304AF; A-8282; C07695; NITROPRUSSIDE SODIUM DIHYDRATE; C5FeN6O.2Na.2H2O; CAS-13755-38-9; CHEBI:9179; D00614; DSSTox_CID_21126; DSSTox_GSID_41126; DSSTox_RID_79630; DTXSID7041126; MFCD00149192; NCGC00166055-03; Na2[Fe(CN)5(NO)].2H2O; Sodium nitroferricyanide dihydrate, 99+%; Sodium nitroferricyanide dihydrate, reagent ACS; Sodium nitroferricyanide(III) dihydrate; Sodium nitroprusside hydrate (JAN)

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1]
Malignant essential hypertension	BA00	Approved	[2]
Sarcopenia	FB32.Y	Approved	[2]

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight; 297.95
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 0
  Hydrogen Bond Donor Count; 2
  Hydrogen Bond Acceptor Count; 14
• ADMET Property:
  Half-life: The concentration or amount of drug in body reduced by one-half in 2 minutes [3]
  Metabolism: The drug is metabolized via reaction with hemoglobin to produce cyanmethemoglobin and cynide ions []
• Chemical Identifiers:
  Formula: C5H4FeN6Na2O3
  IUPAC Name: disodium;iron(4+);nitroxyl anion;pentacyanide;dihydrate
  Canonical SMILES: [C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[N-]=O.O.O.[Na+].[Na+].[Fe+4]
  InChI: XRKMNJXYOFSTBE-UHFFFAOYSA-N
  InChIKey: 1S/5CN.Fe.NO.2Na.2H2O/c5*1-2;;1-2;;;;/h;;;;;;;;;2*1H2/q5*-1;+4;-1;2*+1
• Cross-matching ID:
  PubChem CID: 11953895
  ChEBI ID: CHEBI:9179
  CAS Number: 13755-38-9
  DrugBank ID: DB00325
  INTEDE ID: DR2825
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inositol 1,4,5-trisphosphate receptor (ITPR)	TTC9IZL	ITPR1_HUMAN ; ITPR2_HUMAN ; ITPR3_HUMAN	Antagonist	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
S-(hydroxymethyl)glutathione dehydrogenase (adh) Main DME	DEAH3PE	A0A0A7DS01_VIBCL	Substrate	[5]

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Nitroprusside (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Promazine	DMZAL7W	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Promazine.	Appearance/behaviour symptom [MB23]	[6]
Cariprazine	DMJYDVK	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Cariprazine.	Bipolar disorder [6A60]	[6]
Selegiline	DM6034S	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Selegiline.	Depression [6A70-6A7Z]	[7]
Isocarboxazid	DMAF1NB	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Isocarboxazid.	Depression [6A70-6A7Z]	[7]
Tranylcypromine	DMGB5RE	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Tranylcypromine.	Depression [6A70-6A7Z]	[7]
OPC-34712	DMHG57U	Moderate	Additive hypotensive effects by the combination of Nitroprusside and OPC-34712.	Depression [6A70-6A7Z]	[6]
Phenelzine	DMHIDUE	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Phenelzine.	Depression [6A70-6A7Z]	[7]
Procarbazine	DMIK367	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Procarbazine.	Hodgkin lymphoma [2B30]	[7]
Propiomazine	DMKY8V1	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Propiomazine.	Insomnia [7A00-7A0Z]	[6]
ITI-007	DMUQ1DO	Moderate	Additive hypotensive effects by the combination of Nitroprusside and ITI-007.	Insomnia [7A00-7A0Z]	[6]
Ozanimod	DMT6AM2	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Ozanimod.	Multiple sclerosis [8A40]	[7]
Prochlorperazine	DM53SRA	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Prochlorperazine.	Nausea/vomiting [MD90]	[6]
Thiethylperazine	DMU3IET	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Thiethylperazine.	Nausea/vomiting [MD90]	[6]
Prilocaine	DMI7DZ2	Major	Increased risk of methemoglobinemia by the combination of Nitroprusside and Prilocaine.	Pain [MG30-MG3Z]	[8]
Safinamide	DM0YWJC	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Safinamide.	Parkinsonism [8A00]	[7]
Rasagiline	DM3WKQ4	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Rasagiline.	Parkinsonism [8A00]	[7]
Levomepromazine	DMIKFEL	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Levomepromazine.	Psychotic disorder [6A20-6A25]	[6]
Fluphenazine	DMIT8LX	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Fluphenazine.	Psychotic disorder [6A20-6A25]	[6]
Triflupromazine	DMKFQJP	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Triflupromazine.	Psychotic disorder [6A20-6A25]	[6]
Quetiapine	DM1N62C	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Quetiapine.	Schizophrenia [6A20]	[6]
Mesoridazine	DM2ZGAN	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Mesoridazine.	Schizophrenia [6A20]	[6]
Thioridazine	DM35M8J	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Thioridazine.	Schizophrenia [6A20]	[6]
Aripiprazole	DM3NUMH	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Aripiprazole.	Schizophrenia [6A20]	[6]
Iloperidone	DM6AUFY	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Iloperidone.	Schizophrenia [6A20]	[6]
Paliperidone	DM7NPJS	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Paliperidone.	Schizophrenia [6A20]	[6]
Loxapine	DM8AI9U	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Loxapine.	Schizophrenia [6A20]	[6]
Haloperidol	DM96SE0	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Haloperidol.	Schizophrenia [6A20]	[6]
Perphenazine	DMA4MRX	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Perphenazine.	Schizophrenia [6A20]	[6]
Molindone	DMAH70G	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Molindone.	Schizophrenia [6A20]	[6]
Chlorpromazine	DMBGZI3	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Chlorpromazine.	Schizophrenia [6A20]	[6]
Thiothixene	DMDINC4	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Thiothixene.	Schizophrenia [6A20]	[6]
Clozapine	DMFC71L	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Clozapine.	Schizophrenia [6A20]	[6]
Risperidone	DMN6DXL	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Risperidone.	Schizophrenia [6A20]	[6]
Olanzapine	DMPFN6Y	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Olanzapine.	Schizophrenia [6A20]	[6]
Amisulpride	DMSJVAM	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Amisulpride.	Schizophrenia [6A20]	[6]
Asenapine	DMSQZE2	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Asenapine.	Schizophrenia [6A20]	[6]
Methdilazine	DMAUHQX	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Methdilazine.	Vasomotor/allergic rhinitis [CA08]	[6]
Trimeprazine	DMEMV9D	Moderate	Additive hypotensive effects by the combination of Nitroprusside and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[9]

References

• [1] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 073465.
• [2] Nitroprusside FDA Label
• [3] Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
• [4] Prostacyclin and sodium nitroprusside inhibit the activity of the platelet inositol 1,4,5-trisphosphate receptor and promote its phosphorylation. J Biol Chem. 1996 Mar 8;271(10):5545-51.
• [5] Nitrosative stress response in Vibrio cholerae: role of S-nitrosoglutathione reductase. Appl Biochem Biotechnol. 2017 Jul;182(3):871-884.
• [6] Aronowitz JS, Chakos MH, Safferman AZ, Lieberman JA "Syncope associated with the combination of clozapine and enalapril." J Clin Psychopharmacol 14 (1994): 429-30. [PMID: 7884028]
• [7] Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
• [8] Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
• [9] Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.