Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLXMCB)

Drug Name

COR-D Drug Info

Indication

Disease Entry	ICD 11	Status	REF
T-cell leukaemia	2A90	Preclinical	[1]

Cross-matching ID

TTD Drug ID: DMLXMCB

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Patented Agent(s)

Discontinued Drug(s)

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Drug(s) Targeting Extracellular signal-regulated kinase 1 (ERK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BVD-523	DMNB4XK	Melanoma	2C30	Phase 2	[3]
HH2710	DM0C5MV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
ASTX029	DMVZXIA	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
VAN-10-4-eluting stent	DM3ZW6A	Artery stenosis	BD52	Phase 1	[6]
GDC-0994	DMFC2OY	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
JSI-1187	DMVJWBS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
ASN007	DMYHEUA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine	DMDNG8F	Discovery agent	N.A.	Investigative	[10]
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Drug(s) Targeting Stress-activated protein kinase JNK1 (JNK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NKP-1339	DM5AWK1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[12]
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[12]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[12]
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Drug(s) Targeting Extracellular signal-regulated kinase 2 (ERK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BVD-523	DMNB4XK	Melanoma	2C30	Phase 2	[3]
HH2710	DM0C5MV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
ASTX029	DMVZXIA	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
VAN-10-4-eluting stent	DM3ZW6A	Artery stenosis	BD52	Phase 1	[6]
GDC-0994	DMFC2OY	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
JSI-1187	DMVJWBS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
LY3214996	DMFDAY7	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[13]
SB220025	DMSBUET	Arthritis	FA20	Terminated	[14]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[15]
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Drug(s) Targeting Stress-activated protein kinase JNK2 (JNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[12]
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[12]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[12]
PMID25991433-Compound-J2	DMZSOCK	N. A.	N. A.	Patented	[12]
7-azaindole derivative 3	DMQ7BV4	N. A.	N. A.	Patented	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Extracellular signal-regulated kinase 1 (ERK1)	TT1MG9E	MK03_HUMAN	Activator	[2]
Extracellular signal-regulated kinase 2 (ERK2)	TT4TQBX	MK01_HUMAN	Activator	[2]
Stress-activated protein kinase JNK1 (JNK1)	TT0K6EO	MK08_HUMAN	Activator	[2]
Stress-activated protein kinase JNK2 (JNK2)	TTHS0U8	MK09_HUMAN	Activator	[2]

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References

1	ClinicalTrials.gov (NCT04022863) Ovarium Cancer Detection by TEP's and ctDNA. U.S. National Institutes of Health.
2	Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26.
3	DOI: 10.1158/1538-7445.AM2015-4693
4	Clinical pipeline report, company report or official report of HaiHe Biopharma.
5	Clinical pipeline report, company report or official report of Astex Pharmaceuticals.
6	WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting.
7	ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors
8	National Cancer Institute Drug Dictionary (drug name JSI1187).
9	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10	Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22.
11	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1496).
12	c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.
13	Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.
14	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
15	Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.