Details of the Drug

General Information of Drug (ID: DMLXMCB)

Drug Name
COR-D
Indication
Disease Entry ICD 11 Status REF
T-cell leukaemia 2A90 Preclinical [1]
Drug Type
Small molecular drug
Cross-matching ID
TTD ID
DOJ6D9

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Extracellular signal-regulated kinase 1 (ERK1) TT1MG9E MK03_HUMAN Activator [2]
Extracellular signal-regulated kinase 2 (ERK2) TT4TQBX MK01_HUMAN Activator [2]
Stress-activated protein kinase JNK1 (JNK1) TT0K6EO MK08_HUMAN Activator [2]
Stress-activated protein kinase JNK2 (JNK2) TTHS0U8 MK09_HUMAN Activator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease T-cell leukaemia
ICD Disease Classification 2A90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Stress-activated protein kinase JNK1 (JNK1) DTT MAPK8 1.48E-07 1.2 2.27
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT04022863) Ovarium Cancer Detection by TEP's and ctDNA. U.S. National Institutes of Health.
2 Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26.