Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLZU09)

Drug Name

E-52862 Drug Info

Synonyms

S1RA; UNII-ZW18DSD1H4; ZW18DSD1H4; GTPL10431; MR309; BCP08990; AOB87704; sigma 1 receptor antagonist (S1RA); ZINC95000617; s6754; BDBM50396352; AKOS026750239; SB17181; MCULE-6623106441; CS-2187; compound 28 [PMID: 22784008]; NCGC00371119-04; DA-40938; HY-18099; FT-0700391; E52862; A12504; Q7388203

Indication

Disease Entry	ICD 11	Status	REF
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[1]

Therapeutic Class

Antiviral Agents

Cross-matching ID

PubChem CID: 44247568
CAS Number: CAS 878141-96-9
TTD Drug ID: DMLZU09

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting HUMAN opioid receptor sigma 1 (OPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[2]
PB28	DMMNQ1B	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]
PD-144418	DMJKH28	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]
RS-PPCC	DMN3ZOD	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HUMAN opioid receptor sigma 1 (OPRS1)	TTTPE1L	SGMR1_HUMAN	Antagonist	[2]

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References

1	Synthesis and Biological Evaluation of the 1-arylpyrazole Class of (1) Receptor Antagonists: Identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J Med Chem. 2012 Oct 11;55(19):8211-24.
2	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing