Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM1W9R)

Drug Name

ABTL0812 Drug Info

Synonyms

ABTL-0812; 57818-44-7; alpha-Hydroxylinoleic acid; ABTL0812; (alpha)-Hydroxylinoleic acid; 2-hydroxy-9Z,12Z-Octadecadienoic acid; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoic acid; 0DE74TJ7EZ; 9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-; (9Z,12Z)-2-Hydroxy-9,12-octadecadienoic acid; 9,12-Octadecadienoic acid, 2-hydroxy-, (Z,Z)-; hydroxylinoleic acid; a-Hydroxylinoleic acid; 2-hydroxylinoleic acid; UNII-0DE74TJ7EZ; SCHEMBL320069; CHEBI:136927; DTXSID301258077; .ALPHA.-HYDROXYLINOLEIC ACID; HY-U00141; LMFA02000290; s9611; AKOS040740632; CS-7178; (9Z,12Z)-2-hydroxyoctadecadienoic acid; MS-24253

Indication

Disease Entry	ICD 11	Status	REF
Pancreatic cancer	2C10	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 21158511
TTD Drug ID: DMM1W9R

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Peroxisome proliferator-activated receptor (PPAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
A278	DMKXO9V	Non-alcoholic steatohepatitis	DB92.1	IND submitted	[3]
IVA337	DMJV3AX	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peroxisome proliferator-activated receptor (PPAR)	TTRMIZ7	PPARA_HUMAN; PPARD_HUMAN; PPARG_HUMAN	Agonist	[2]

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References

1	ClinicalTrials.gov (NCT04431258) A Phase I Open Label Followed by a Phase II Randomized, Controlled Study to Assess the Efficacy and Safety of ABTL0812 in Combination With FOLFIRINOX for First-line Treatment of Metastatic Pancreatic. U.S.National Institutes of Health.
2	The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells. Autophagy. 2021 Jun;17(6):1349-1366.
3	Clinical pipeline report, company report or official report of Klus Pharma
4	Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension. Ann Rheum Dis. 2017 Nov;76(11):1931-1940.