General Information of Drug (ID: DMM1W9R)

Drug Name
ABTL0812
Synonyms
ABTL-0812; 57818-44-7; alpha-Hydroxylinoleic acid; ABTL0812; (alpha)-Hydroxylinoleic acid; 2-hydroxy-9Z,12Z-Octadecadienoic acid; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoic acid; 0DE74TJ7EZ; 9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-; (9Z,12Z)-2-Hydroxy-9,12-octadecadienoic acid; 9,12-Octadecadienoic acid, 2-hydroxy-, (Z,Z)-; hydroxylinoleic acid; a-Hydroxylinoleic acid; 2-hydroxylinoleic acid; UNII-0DE74TJ7EZ; SCHEMBL320069; CHEBI:136927; DTXSID301258077; .ALPHA.-HYDROXYLINOLEIC ACID; HY-U00141; LMFA02000290; s9611; AKOS040740632; CS-7178; (9Z,12Z)-2-hydroxyoctadecadienoic acid; MS-24253
Indication
Disease Entry ICD 11 Status REF
Pancreatic cancer 2C10 Phase 1/2 [1]
Drug Type
Small molecule
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C18H32O3
Canonical SMILES
CCCCCC=CCC=CCCCCCCC(C(=O)O)O
InChI
InChI=1S/C18H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h6-7,9-10,17,19H,2-5,8,11-16H2,1H3,(H,20,21)/b7-6-,10-9-
InChIKey
AFDSETGKYZMEEA-HZJYTTRNSA-N
Cross-matching ID
PubChem CID
21158511
TTD ID
DMBQ10

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Peroxisome proliferator-activated receptor (PPAR) TTRMIZ7 PPARA_HUMAN ; PPARD_HUMAN ; PPARG_HUMAN Agonist [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT04431258) A Phase I Open Label Followed by a Phase II Randomized, Controlled Study to Assess the Efficacy and Safety of ABTL0812 in Combination With FOLFIRINOX for First-line Treatment of Metastatic Pancreatic. U.S.National Institutes of Health.
2 The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells. Autophagy. 2021 Jun;17(6):1349-1366.