Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM4ZKU)

Drug Name

ZAPOTIN Drug Info

Synonyms

Zapotin; 14813-19-5; CHEMBL375582; 5,6,2',6'-tetramethoxyflavone; 2-(2,6-dimethoxyphenyl)-5,6-dimethoxychromen-4-one; Flavone, 2',5,6,6'-tetramethoxy-; AC1LCGQ2; SCHEMBL3307703; 2',6',5,6-Tetramethoxyflavon; DTXSID80348078; 2-(2,6-Dimethoxyphenyl)-5,6-dimethoxy-4H-chromen-4-one; PBQMALAAFQMDSP-UHFFFAOYSA-N; 2',5,6,6'-Tetramethoxyflavone; MolPort-005-945-165; 4H-1-Benzopyran-4-one, 2-(2,6-dimethoxyphenyl)-5,6-dimethoxy-; 5,6,2'',6''-tetramethoxyflavone; ZINC14756841; LMPK12110091; Flavone,2',5,6,6'-tetramethoxy-; BDBM50202558

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 629965
CAS Number: CAS 14813-19-5
TTD Drug ID: DMM4ZKU

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eflornithine	DMJOQM3	African trypanosomiasis	1F51	Approved	[2]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[3]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[3]
G418	DMKTJBU	Discovery agent	N.A.	Investigative	[3]
Pyridoxine-5'-Phosphate	DMFUNL1	Discovery agent	N.A.	Investigative	[3]
APA	DMVG3K1	Discovery agent	N.A.	Investigative	[4]
AMXT-1501	DMPSRZ0	Head and neck cancer	2D42	Investigative	[5]
(2R,5R)-delta-methyl-alpha-acetylenic putrescine	DMSFXEO	Discovery agent	N.A.	Investigative	[2]
LONCHOCARPUSONE	DMWFAPJ	Discovery agent	N.A.	Investigative	[6]
Alpha-monofluoromethyl-3,4-dehydroornithine methyl ester	DMGI9SM	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ornithine decarboxylase (ODC1)	TTUMGNO	DCOR_HUMAN	Inhibitor	[1]

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References

1	Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5.
2	Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1276).
6	New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10.