Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM632N)

Drug Name

3,6,8-Tribromo-dibenzo[1,4]dioxin-1-ol Drug Info

Synonyms

Spongiadioxin C; CHEMBL185753; 3,6,8-Tribromo-dibenzo[1,4]dioxin-1-ol; 3,6,8-tribromooxanthren-1-ol; dibenzo[b,e][1,4]dioxin-1-ol, 3,6,8-tribromo-; 3,6,8-tribromodibenzo[b,e][1,4]dioxin-1-ol; AC1LCT04; BDBM50150791; 3,6,8-tribromodibenzo-p-dioxin-1-ol; 460092-06-2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 636835
TTD Drug ID: DMM632N

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indolizine derivative 1	DM4GZBI	N. A.	N. A.	Patented	[2]
Imidazole derivative 10	DMI7W3K	N. A.	N. A.	Patented	[3]
Indole and benzimidazole derivative 1	DMS0169	N. A.	N. A.	Patented	[3]
Triazole derivative 3	DMZR0TH	N. A.	N. A.	Patented	[3]
Isothiazolone derivative 1	DMHAJCM	N. A.	N. A.	Patented	[3]
PMID26560362-Compound-90	DM9V13U	N. A.	N. A.	Patented	[3]
Imidazole derivative 11	DMTJ0DP	N. A.	N. A.	Patented	[3]
Tri-substituted benzene derivative 1	DMEQ3RD	N. A.	N. A.	Patented	[3]
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[4]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 15-lipoxygenase (15-LOX)	TTN9T81	LOX15_HUMAN	Inhibitor	[1]

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References

1	Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.
2	Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
3	15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
4	Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
5	Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.