Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM6CJI)

Drug Name

11-keto-beta-boswellicacid Drug Info

Synonyms

11-Keto-beta-boswellic acid; UNII-0S3BIF6H0Q; 11-Keto Boswellic Acid; 0S3BIF6H0Q; 17019-92-0; CHEMBL437964; 11-Oxo-beta-boswellic acid; (4R)-3alpha-hydroxy-11-oxo-urs-12-en-23-oic acid; Keto-b-boswellic acid; 3alpha-Hydroxy-11-oxours-12-en-24-oic acid; 11-Oxo-; 11-Keto-; BETA-BOSWELLIC ACID,11-KETO; A-Hydroxy-11-oxours-12-en-24-oic acid; 11-Oxo-b-boswellic acid; 11-Keto-b-boswellic acid; SCHEMBL4388405; (3alpha,4beta)-3-Hydroxy-11-oxours-12-en-23-oic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9847548
CAS Number: CAS 17019-92-0
TTD Drug ID: DMM6CJI

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RG-7234	DM5RAB9	Type-2 diabetes	5A11	Phase 2	[2]
[(125)I] RB129	DMX0G7E	Discovery agent	N.A.	Investigative	[3]
3-acetyl-11-keto-beta-boswellic acid	DMGO2D7	Discovery agent	N.A.	Investigative	[1]
Ganoderic acid A	DM42EVG	Discovery agent	N.A.	Investigative	[1]
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Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GLYCYRRHIZIN	DM8M2N3	Influenza virus infection	1E30-1E32	Phase 3	[4]
BVT.2733	DM6RUKX	Lupus	4A40	Phase 3	[5]
INCB13739	DMLQ3PO	Type-2 diabetes	5A11	Phase 2a	[6]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[1]
JTT-654	DM50M2R	Type-2 diabetes	5A11	Phase 2	[2]
RG-4929	DMT4QRD	Metabolic disorder	5C50-5D2Z	Phase 2	[2]
BMS-770767	DMTVGY7	Hypercholesterolaemia	5C80.0	Phase 2	[2]
UE-2343	DMIERPK	Alzheimer disease	8A20	Phase 2	[7]
AZD-4017	DML9M5S	Ocular hypertension	9C61.01	Phase 2	[2]
Xanamem	DM580GT	Alzheimer disease	8A20	Phase 1/2	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[1]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	TT9H85R	DHI2_HUMAN	Inhibitor	[1]

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References

1	11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.
2	New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131).
3	Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation. Oncogene. 2003 Mar 20;22(11):1663-7.
4	Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. Bioorg Med Chem. 2009 Aug 1;17(15):5722-32.
5	Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology. 2003 Nov;144(11):4755-62.
6	Incyte's Selective Oral Inhibitor Of 11beta-HSD1 Demonstrates Improvements In Insulin Sensitivity And Lowers Cholesterol Levels In Type 2 Diabetics. Incyte. 2008.
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8	Selection and early clinical evaluation of the brain-penetrant 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor UE2343 (Xanamem?). Br J Pharmacol. 2017 Mar;174(5):396-408.