Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM731A)

Drug Name

N-Me-aminopyrimidinone 9 Drug Info

Synonyms

N-Me-aminopyrimidinone 9; CHEMBL1938867; 1356834-62-2; GTPL5733; BDBM50362580; ZINC73167698; BC600825; 6-amino-2-[(4-tert-butylphenyl)methylsulfanyl]-3-methylpyrimidin-4-one.

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 56951318
TTD Drug ID: DMM731A

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.7 (SCN9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
XEN-402	DMR69CG	Osteoarthritis	FA00-FA05	Phase 2	[3]
PF-05089771	DMD74BJ	Chronic pain	MG30	Phase 2	[4]
BIIB074	DMLV1ET	Bipolar disorder	6A60	Phase 2	[5]
DSP-2230	DM0WTMD	Neuropathic pain	8E43.0	Phase 1	[5]
BIIB095	DMUC6EP	Pain	MG30-MG3Z	Phase 1	[5]
GDC0310	DMUNFEP	Chronic pain	MG30	Phase 1	[6]
DSP-3905	DMYHU24	Neuropathic pain	8E43.0	Phase 1	[5]
PF-05241328	DM2NTBL	Pain	MG30-MG3Z	Phase 1	[7]
DWJ-208	DMQKDJZ	Cancer related pain	MG30	Phase 1	[5]
RG7893	DM1R4MQ	Pain	MG30-MG3Z	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.7 (SCN9A)	TT4G2JS	SCN9A_HUMAN	Inhibitor (gating inhibitor)	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5733).
2	Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1055-60.
3	Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker. Pain. 2012 Jan;153(1):80-5.
4	Primary erythromelalgia: a review. Orphanet J Rare Dis. 2015 Sep 30;10:127.
5	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Recent progress in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.
8	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800041740)