Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMHQYB)

Drug Name

phosphatidyl (3,5) inositol biphosphate Drug Info

Synonyms

phosphatidylinositol 3,5-bisphosphate; PI(3,5)P2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Mucolipin-1 (TRPML1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MK6-83	DMI3E0Y	Discovery agent	N.A.	Preclinical	[5]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mucolipin-1 (TRPML1)	TT9XBVO	MCLN1_HUMAN	Activator	[2]
Two pore calcium channel protein 1 (TPC1)	TTODQE2	TPC1_HUMAN	Activator	[3]
Two pore calcium channel protein 2 (TPC2)	TTZWC8B	TPC2_HUMAN	Activator	[4]

------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2794).
2	PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun. 2010 Jul 13;1:38.
3	The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nat Chem Biol. 2014 Jun;10(6):463-9.
4	TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 2012 Oct 12;151(2):372-83.
5	ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Oct;182:104922.