Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMHR1U)

Drug Name

Denileukin diftitox Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Epithelial ovarian cancer	2B5D	Approved	[1]
leukaemia	2A60-2B33	Approved	[2]
Plasma cell myeloma	2A83.1	Approved	[1]
Primary cutaneous T-cell lymphoma		Approved	[3]
Non-small-cell lung cancer	2C25.Y	Phase 2	[2]

Therapeutic Class

Anticancer Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Interleukin 2 receptor (IL2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALKS 4230	DME3ZYC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[5]
Ro26-4550	DMGL7TM	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7044).
3	Advanced-stage primary cutaneous T-cell lymphoma treated with bexarotene and denileukin diftitox. Case Rep Dermatol. 2011 Jan;3(1):13-7.
4	Optimizing denileukin diftitox (Ontak) therapy. Future Oncol. 2008 Aug;4(4):457-69.
5	ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer. 2020 Apr;8(1):e000673.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2297).