DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Roflumilast |
DMPGHY8
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Roflumilast. |
Asthma [CA23]
|
[6] |
Ofloxacin |
DM0VQN3
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Ofloxacin. |
Bacterial infection [1A00-1C4Z]
|
[7] |
Ciprofloxacin XR |
DM2NLS9
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Ciprofloxacin XR. |
Bacterial infection [1A00-1C4Z]
|
[7] |
Trovafloxacin |
DM6AN32
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Trovafloxacin. |
Bacterial infection [1A00-1C4Z]
|
[7] |
Sparfloxacin |
DMB4HCT
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Sparfloxacin. |
Bacterial infection [1A00-1C4Z]
|
[7] |
Gemifloxacin |
DMHT34O
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Gemifloxacin. |
Bacterial infection [1A00-1C4Z]
|
[7] |
Norfloxacin |
DMIZ6W2
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Norfloxacin. |
Bacterial infection [1A00-1C4Z]
|
[7] |
ABT-492 |
DMJFD2I
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by ABT-492. |
Bacterial infection [1A00-1C4Z]
|
[7] |
Levofloxacin |
DMS60RB
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Levofloxacin. |
Bacterial infection [1A00-1C4Z]
|
[7] |
Moxifloxacin |
DMU8V4S
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Moxifloxacin. |
Bacterial infection [1A00-1C4Z]
|
[7] |
Lomefloxacin |
DMVRH9C
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Lomefloxacin. |
Bacterial infection [1A00-1C4Z]
|
[7] |
Grepafloxacin |
DMGLX0T
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Grepafloxacin. |
Bronchitis [CA20]
|
[7] |
Teriflunomide |
DMQ2FKJ
|
Major |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Teriflunomide. |
Hyper-lipoproteinaemia [5C80]
|
[8] |
Denosumab |
DMNI0KO
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Denosumab. |
Low bone mass disorder [FB83]
|
[9] |
Cladribine |
DM3JDRP
|
Major |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Cladribine. |
Mature B-cell leukaemia [2A82]
|
[6] |
Alemtuzumab |
DMZL3IV
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Alemtuzumab. |
Mature B-cell leukaemia [2A82]
|
[10] |
Thalidomide |
DM70BU5
|
Major |
Additive thrombogenic effects by the combination of Denileukin diftitox and Thalidomide. |
Multiple myeloma [2A83]
|
[11] |
Tecfidera |
DM2OVDT
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Tecfidera. |
Multiple sclerosis [8A40]
|
[12] |
Siponimod |
DM2R86O
|
Major |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Siponimod. |
Multiple sclerosis [8A40]
|
[13] |
Fingolimod |
DM5JVAN
|
Major |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Fingolimod. |
Multiple sclerosis [8A40]
|
[14] |
Ocrelizumab |
DMEZ2KH
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Ocrelizumab. |
Multiple sclerosis [8A40]
|
[15] |
Ozanimod |
DMT6AM2
|
Major |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Ozanimod. |
Multiple sclerosis [8A40]
|
[6] |
Omacetaxine mepesuccinate |
DMPU2WX
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Omacetaxine mepesuccinate. |
Myeloproliferative neoplasm [2A20]
|
[16] |
Efalizumab |
DMCKL5V
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Efalizumab. |
Psoriasis [EA90]
|
[17] |
Infliximab |
DMH7OIA
|
Major |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Infliximab. |
Psoriasis [EA90]
|
[18] |
Gatifloxacin |
DMSL679
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Gatifloxacin. |
Respiratory infection [CA07-CA4Z]
|
[7] |
Canakinumab |
DM8HLO5
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Canakinumab. |
Rheumatoid arthritis [FA20]
|
[19] |
Etanercept |
DMCV109
|
Major |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Etanercept. |
Rheumatoid arthritis [FA20]
|
[18] |
Rilonacept |
DMGLUQS
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Rilonacept. |
Rheumatoid arthritis [FA20]
|
[19] |
Golimumab |
DMHZV7X
|
Major |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Golimumab. |
Rheumatoid arthritis [FA20]
|
[18] |
Adalimumab |
DMQMV1B
|
Major |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Adalimumab. |
Rheumatoid arthritis [FA20]
|
[18] |
Leflunomide |
DMR8ONJ
|
Major |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Leflunomide. |
Rheumatoid arthritis [FA20]
|
[8] |
Anakinra |
DMU8KOD
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Anakinra. |
Rheumatoid arthritis [FA20]
|
[19] |
Anthrax vaccine |
DM9GSWY
|
Moderate |
Antagonize the effect of Denileukin diftitox when combined with Anthrax vaccine. |
Sepsis [1G40-1G41]
|
[20] |
Azathioprine |
DMMZSXQ
|
Moderate |
Additive immunosuppressive effects by the combination of Denileukin diftitox and Azathioprine. |
Transplant rejection [NE84]
|
[13] |
Cinoxacin |
DM4EWNS
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Cinoxacin. |
Urinary tract infection [GC08]
|
[7] |
Nalidixic acid |
DMRM0JV
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Nalidixic acid. |
Urinary tract infection [GC08]
|
[7] |
Enoxacin |
DMYTE6L
|
Minor |
Decreased absorption of Denileukin diftitox due to intestinal mucosa variation caused by Enoxacin. |
Urinary tract infection [GC08]
|
[7] |
Ganciclovir |
DM1MBYQ
|
Moderate |
Increased risk of nephrotoxicity by the combination of Denileukin diftitox and Ganciclovir. |
Virus infection [1A24-1D9Z]
|
[13] |
Valganciclovir |
DMS2IUH
|
Moderate |
Increased risk of nephrotoxicity by the combination of Denileukin diftitox and Valganciclovir. |
Virus infection [1A24-1D9Z]
|
[13] |
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