Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMJFTR)

Drug Name
Non-PEGylated butyrylcholinesterase Drug Info
Synonyms
Non-PEGylated butyrylcholinesterase (recombinant human, nerve agent exposure); Non-PEGylated butyrylcholinesterase (recombinant human, nerve agent exposure), PharmAthene; Non-PEG-rBChE (toxicity/alzheimers disease), PharmAthene
Indication
Disease Entry ICD 11 Status REF
Toxicity N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DMMJFTR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Cholinesterase (BCHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hexafluronium bromide DMFY307 Spasm MB47.3 Approved [2]
MEPTAZINOL DMPSB8F Pain MG30-MG3Z Approved [3]
Eptastigmine DMTV7ZM Cognitive impairment 6D71 Phase 3 [4]
(-)-Phenserine DMNCY1I Alzheimer disease 8A20 Phase 3 [5]
Plasma derived human butyrylcholinesterase DMF3IBC Neurotoxicity NE61 Phase 1 [6]
Protexia DME1Y9W Alzheimer disease 8A20 Phase 1 [7]
JES-9501 DMYR3IE Alzheimer disease 8A20 Phase 1 [8]
Tetra-hydro-isoquinoline derivative 3 DMCZA45 N. A. N. A. Patented [9]
Tetra-hydro-isoquinoline derivative 1 DML86IO N. A. N. A. Patented [9]
Tetra-hydro-isoquinoline derivative 2 DM5CKVF N. A. N. A. Patented [9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cholinesterase (BCHE) TTEB0GD CHLE_HUMAN Modulator [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2471).
2 Synergistic effect of acidosis and succinylcholine-induced hyperkalemia in spinal cord transected rats. Acta Anaesthesiol Scand. 1984 Feb;28(1):87-90.
3 Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36.
4 Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J Med Chem. 2006 Apr 6;49(7):2174-85.
5 Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93.
6 Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Bioconjug Chem. 2015 Aug 19;26(8):1753-8.
7 In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chem Biol Interact. 2005 Dec 15;157-158:363-5.
8 Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice. Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5.
9 A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465.