Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMSIG7)

Drug Name
DM-71 Drug Info
Synonyms Insulin sensitizer (type 2 diabetes), DiaMedica; Bethanechol + n-acetyl cysteine (type 2 diabetes), DiaMedica
Indication
Disease Entry ICD 11 Status REF
Type-2 diabetes 5A11 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMMSIG7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Insulin receptor (INSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meglitinides DM1OFHN Type-2 diabetes 5A11 Approved [3]
Human neutral insulin DMA5OBU Diabetic complication 5A2Y Approved [4]
Insulin Lyspro recombinant DM5XHVR Diabetic complication 5A2Y Approved [4]
Insulin, porcine DMO95XI Diabetic complication 5A2Y Approved [5]
Insulin recombinant DMYVP5G Diabetic complication 5A2Y Approved [4]
Metformin arginine-hemisuccinimide DMTPAM3 Type-2 diabetes 5A11 Approved [6]
Insulin-lispro DM4O90W Diabetic complication 5A2Y Approved [7]
Insulin-glulisine DMQI0FU Diabetic complication 5A2Y Approved [8]
Ryzodeq DMOFP18 Type-2 diabetes 5A11 Approved [2]
NN5401 DM0QV27 Diabetic complication 5A2Y Phase 3 [2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Insulin receptor (INSR) TTCBFJO INSR_HUMAN Modulator [2]

References

1 Clinical pipeline report, company report or official report of DiaMedica Inc.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800).
3 New drugs for type 2 diabetes mellitus: what is their place in therapy Drugs. 2008;68(15):2131-62.
4 Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
5 Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor. J Biochem. 2002 Jun;131(6):855-9.
6 Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase. Biochem Pharmacol. 2004 Jun 1;67(11):2081-91.
7 Hope for insulin mimetic oral antidiabetic drugs. Eur J Endocrinol. 1999 Dec;141(6):561-2.
8 Insulin glulisine: a review of its use in the management of diabetes mellitus. Drugs. 2009;69(8):1035-57.