Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMUS8X)

Drug Name

AMG 108 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Interleukin 1 receptor type 2 (IL1R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK-1827771	DMA41JD	Rheumatoid arthritis	FA20	Phase 1	[3]
FR-133605	DMXWL0N	Arthritis	FA20	Terminated	[4]
MRL-953	DM4A92X	Immune System disease	4A01-4B41	Terminated	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 1 receptor type 2 (IL1R2)	TT51DEV	IL1R2_HUMAN	Antagonist	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020487)
2	Clinical pipeline report, company report or official report of Amgen (2009).
3	WO patent application no. 2013,0077,63, Modulators of the nlrp3 inflammasome il-1ss pathway for the prevention and treatment of acne.
4	Effect of FR133605, a novel cytokine suppressive agent, on bone and cartilage destruction in adjuvant arthritic rats. J Rheumatol. 1996 Oct;23(10):1778-83.
5	SDZ MRL 953, a lipid A analog as selective cytokine inducer. Prog Clin Biol Res. 1995;392:549-65.