Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMUYC2)

Drug Name

YM-344031 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting C-C chemokine receptor type 3 (CCR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AKST4290	DM27ZJG	Parkinson disease	8A00.0	Phase 2	[2]
AZD-1744	DMCOMG5	Asthma	CA23	Discontinued in Phase 1	[3]
DPC-168	DMA7DH0	Allergic rhinitis	CA08.0	Discontinued in Phase 1	[4]
YM-355179	DMTM1LK	Asthma	CA23	Preclinical	[1]
QAP-642	DM8RHST	Allergic rhinitis	CA08.0	Terminated	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 3 (CCR3)	TTD3XFU	CCR3_HUMAN	Antagonist	[1]

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References

1	Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.
2	SAFETY AND THERAPEUTIC EFFECTS OF ORALLY ADMINISTERED AKST4290 IN NEWLY DIAGNOSED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina. 2022 Jun 1;42(6):1038-1046.
3	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4	CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2992-7.
5	New Drugs and Targets for Asthma and COPD. T.T. Hansel, P.J. Barnes. 2010. Page 158.