Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMWCLV)

• Drug Name: SB-221420-A Drug Info
• Synonyms: SB-221420-A

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Investigative	[1]

• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 9843561
  TTD Drug ID: DMMWCLV

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.9 (SCN11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[2]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[3]
Lacosamide	DMVM6QR	Convulsion	8A68.Z	Approved	[4]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[5]
Tolperisone	DMA2GHJ	Muscle spasm	MB47.3	Approved	[6]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[7]
Eslicarbazepine	DMZREFQ	Seizure disorder	8A6Z	Approved	[4]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[8]
HP-184	DMNOMV2	Multiple sclerosis	8A40	Phase 2	[9]
QX-314	DMAV2FM	Pain	MG30-MG3Z	Terminated	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.9 (SCN11A)	TTN9VTF	SCNBA_HUMAN	Blocker	[1]

References

• [1] Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95.
• [2] Mechanisms of analgesia of intravenous lidocaine. Rev Bras Anestesiol. 2008 May-Jun;58(3):280-6.
• [3] The effects of lamotrigine on the acquisition and expression of morphine-induced place preference in mice. Pak J Biol Sci. 2009 Jan 1;12(1):33-9.
• [4] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [5] Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole. Prog Brain Res. 2002;137:177-90.
• [6] Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46.
• [7] New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22.
• [8] Debate: Does genetic information in humans help us treat patients PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all. Epilepsia. 2008 Dec;49 Suppl 9:13-24.
• [9] Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80.
• [10] Voltage-gated sodium channel blockers for the treatment of chronic pain. Curr Top Med Chem. 2009;9(4):362-76.