Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN3GTF)

Drug Name

DABCO-C16 Drug Info

Synonyms

TA279; C16-1,4-Diazabicyclo[2.2.2]octane

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Voltage-gated potassium channel Kv3.4 (KCNC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[2]
DABCO	DMHZKMG	Discovery agent	N.A.	Investigative	[1]
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Drug(s) Targeting Voltage-gated potassium channel Kv2.1 (KCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[3]
RY796	DMW4850	Discovery agent	N.A.	Investigative	[4]
3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol	DMZ8WMA	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated potassium channel Kv2.1 (KCNB1)	TT5OEKU	KCNB1_HUMAN	Blocker (channel blocker)	[1]
Voltage-gated potassium channel Kv3.4 (KCNC4)	TTODZF1	KCNC4_HUMAN	Blocker (channel blocker)	[1]

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References

1	1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar;69(3):718-26.
2	Characterization of a Shaw-related potassium channel family in rat brain. EMBO J. 1992 Jul;11(7):2473-86.
3	Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25. Biochem J. 2006 Jun 1;396(2):363-9.
4	Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64.
5	Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast. Mol Pharmacol. 2004 Jan;65(1):214-9.