General Information of Drug (ID: DMN9RE5)

Drug Name
AEZS-131 Drug Info
Synonyms ERK inhibitor (cancer), AEterna
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Cross-matching ID
TTD Drug ID
DMN9RE5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BVD-523 DMNB4XK Melanoma 2C30 Phase 2 [2]
HH2710 DM0C5MV Solid tumour/cancer 2A00-2F9Z Phase 1/2 [3]
ASTX029 DMVZXIA Solid tumour/cancer 2A00-2F9Z Phase 1/2 [4]
VAN-10-4-eluting stent DM3ZW6A Artery stenosis BD52 Phase 1 [5]
GDC-0994 DMFC2OY Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
JSI-1187 DMVJWBS Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
LY3214996 DMFDAY7 Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
CHIR-99021 DMB8MNU Allergic inflammation 4A80-4A85 Patented [9]
COR-D DMLXMCB T-cell leukaemia 2A90 Preclinical [10]
SB220025 DMSBUET Arthritis FA20 Terminated [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Extracellular signal-regulated kinase 2 (ERK2) TT4TQBX MK01_HUMAN Inhibitor [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1495).
2 DOI: 10.1158/1538-7445.AM2015-4693
3 Clinical pipeline report, company report or official report of HaiHe Biopharma.
4 Clinical pipeline report, company report or official report of Astex Pharmaceuticals.
5 WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting.
6 ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors
7 National Cancer Institute Drug Dictionary (drug name JSI1187).
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.
10 Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26.
11 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.