Details of the Drug-Related molecule(s) Interaction Atlas

Phthalazinone derivative 1 Drug Info

PMID28627961-Compound-23

Cross-matching ID

PubChem CID

71525311

TTD Drug ID

DMNA941

General Information of Drug (ID: DMNA941)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Prostaglandin E synthase (PTGES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AAD-2004	DMG4RK0	Alzheimer disease	8A20	Phase 1	[2]
Carboxylic acid derivative 1	DM86E2P	Angiogenesis disorder	BE2Z	Patented	[1]
Benzamide derivative 18	DMD7640	N. A.	N. A.	Patented	[1]
Betais-sulfonylamino derivative 1	DMMCDR7	N. A.	N. A.	Patented	[1]
Benzimidazole derivative 13	DMV4DQI	N. A.	N. A.	Patented	[1]
Benzamide derivative 16	DMOAXKF	N. A.	N. A.	Patented	[1]
Imidazopyridine derivative 5	DMUKBGD	N. A.	N. A.	Patented	[1]
Imidazopyridine derivative 6	DMA0V4F	N. A.	N. A.	Patented	[1]
PMID28627961-Compound-22	DM36P7T	N. A.	N. A.	Patented	[1]
Imidazole benzamide derivative 1	DM0SOKJ	Knee pain	ME82	Patented	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin E synthase (PTGES)	TTYLQ8V	PTGES_HUMAN	Inhibitor	[1]

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References

1	Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059.
2	Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.