Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNC1AS)

• Drug Name: INZ-701 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hypophosphatemic rickets	5C63.22	Phase 1/2	[1]
Pseudoxanthoma elasticum	EC40	Phase 1/2	[2]

• Cross-matching ID: TTD Drug ID: DMNC1AS

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)	TTZTIWS	ENPP1_HUMAN	Replacement	[3]

References

• [1] ClinicalTrials.gov (NCT04686175) A Phase 1/2, Open-Label, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INZ-701 Followed by an Open-Label Long-Term Extension Period in Adults With ENPP1 Deficiency. U.S.National Institutes of Health.
• [2] ClinicalTrials.gov (NCT05030831) A Phase 1/2, Open-Label, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INZ-701 Followed by an Open-Label Long-Term Extension Period in Adults With ABCC6 Deficiency Manifesting as Pseudoxanthoma Elasticum (PXE). U.S.National Institutes of Health.
• [3] Clinical pipeline report, company report or official report of Inozyme pharma