Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNHU4M)

Drug Name
TRIM Drug Info
Synonyms
Trim; 25371-96-4; 1-[2-(trifluoromethyl)phenyl]imidazole; 1-(2-Trifluoromethylphenyl)imidazole; 1-(2-(Trifluoromethyl)phenyl)-1H-imidazole; 1-[2-(Trifluoromethyl)phenyl]-1H-imidazole; CHEMBL277525; WZBWBNCQUTXYEL-UHFFFAOYSA-N; NCGC00016047-03; 1H-Imidazole,1-[2-(trifluoromethyl)phenyl]-; DSSTox_RID_80756; DSSTox_CID_25217; DSSTox_GSID_45217; [2-(trifluoromethyl)phenyl]imidazole; 1-TRIM; CAS-25371-96-4; SR-01000076173; PubChem6489; Tocris-0919; ACMC-1CKKY; AC1L1BAW; AC1Q4JVD; Lopac-T-7313; Lopac0_001200; KBioSS_000064
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1359
ChEBI ID
CHEBI:109530
CAS Number
CAS 25371-96-4
TTD Drug ID
DMNHU4M

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Transient receptor potential cation channel V2 (TRPV2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [2]
2-APB DM9AKVR Discovery agent N.A. Investigative [2]
lysophosphatidylcholine DMOGFVH Discovery agent N.A. Investigative [3]
diphenylboronic anhydride DMRQZTS Discovery agent N.A. Investigative [2]
lysophosphatidylinositol DMETM3R Discovery agent N.A. Investigative [3]
citral DM53ZGY Discovery agent N.A. Investigative [4]
cannabinol DMM6A7P Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transient receptor potential cation channel V2 (TRPV2) TTBECWA TRPV2_HUMAN Blocker (channel blocker) [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4331).
2 Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxy... Mol Pharmacol. 2007 Nov;72(5):1258-68.
3 Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta. 2009 Mar;1793(3):528-39.
4 Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 7;3(5):e2082.
5 TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci. 2008 Jun 11;28(24):6231-8.