Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNJVR6)

• Drug Name: Heterocyclic-tetracyclic tetrahydrofuran derivative 1 Drug Info
• Synonyms: PMID26609882-Compound-49
• Cross-matching ID: TTD Drug ID: DMNJVR6

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 2 receptor (5HT2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mianserin	DMVKA4O	Depression	6A70-6A7Z	Approved	[2]
Cyclobenzaprine	DM1YBRM	Depression	6A70-6A7Z	Approved	[3]
Perospirone	DMVHJLX	Psychotic disorder	6A20-6A25	Approved	[4]
Ketanserin	DMVLMW6	Hypertension	BA00-BA04	Approved	[5]
Bis(olanzapine) pamoate monohydrate	DME76AP	Psychotic disorder	6A20-6A25	Phase 3	[6]
FKB01MD	DM2O7NM	N. A.	N. A.	Phase 2	[7]
Nexopamil	DML5S71	Hypertension	BA00-BA04	Phase 2	[8]
TGWOOAA	DMI57ZA	Generalized anxiety disorder	6B00	Phase 2	[9]
TGOF02N	DMQ6ANE	Schizophrenia	6A20	Phase 2	[10]
AMAP-102	DM7CD8Z	Arthritis	FA20	Phase 1	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2 receptor (5HT2R)	TTYSN63	NOUNIPROTAC	Antagonist	[1]

References

• [1] Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106.
• [2] 5-HT reuptake and 5-HT2 receptors modulate capsaicin-evoked hypothermia in rats. Neurosci Lett. 2008 Jan 17;430(3):191-6.
• [3] Torticollis under Cyclobenzaprine. Pharmacology. 2009 Jul 8;84(2):91-92.
• [4] Pharmacological effects of zotepine and other antipsychotics on the central 5-HT2 receptors. Pharmacopsychiatry. 1993 Mar;26(2):53-8.
• [5] Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L531-8.
• [6] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94.
• [9] Clinical pipeline report, company report or official report of Fabre-Kramer Pharmaceuticals.
• [10] Clinical pipeline report, company report or official report of Fabre-Kramer Pharmaceuticals.
• [11] Clinical pipeline report, company report or official report of Anamar.