Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNKC9J)

Drug Name
Cbz-Ile-t-ButylhomoGlu-Ala-LeuVSMe Drug Info
Synonyms CHEMBL207196; Cbz-Ile-t-ButylhomoGlu-Ala-LeuVSMe
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11513217
TTD Drug ID
DMNKC9J

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cathepsin B (CTSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [2]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [2]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [2]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [2]
PMID27998201-Compound-11 DMTV5NU Metastatic cancer 2D50-2E2Z Patented [2]
PMID27998201-Compound-2 DMMAE3C Alzheimer disease 8A20 Patented [2]
PMID27998201-Compound-22 DMS9QA7 Alzheimer disease 8A20 Patented [2]
PMID27998201-Compound-13 DMZHIM8 Hepatic fibrosis DB93.0 Patented [2]
Dimethoxybenzylidene-2-thio-imidazole-4-one derivative 1 DMZ4B3W Cerebral ischemia 8B11 Patented [2]
PMID27998201-Compound-24 DM25BNZ Glioma 2A00.0 Patented [2]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin S (CTSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RG7625 DMDGPKS Autoimmune disease 4A40-4A45 Phase 2 [3]
SAR-114137 DMZ1XR5 Pain MG30-MG3Z Phase 1 [4]
VBY- 891 DMTKPH4 Autoimmune diabetes 5A10 Phase 1 [5]
VBY- 036 DMULRYC Neuropathic pain 8E43.0 Phase 1 [6]
VBY-129 DM4YIWK Autoimmune diabetes 5A10 Phase 1 [7]
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [2]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [2]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [2]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [8]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [2]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cathepsin B (CTSB) TTF2LRI CATB_HUMAN Inhibitor [1]
Cathepsin S (CTSS) TTUMQVO CATS_HUMAN Inhibitor [1]

References

1 Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68.
2 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353).
6 Clinical pipeline report, company report or official report of ViroBay.
7 Clinical pipeline report, company report or official report of ViroBay.
8 An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.