General Information of Drug (ID: DMNKC9J)

Drug Name
Cbz-Ile-t-ButylhomoGlu-Ala-LeuVSMe Drug Info
Synonyms CHEMBL207196; Cbz-Ile-t-ButylhomoGlu-Ala-LeuVSMe
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11513217
TTD Drug ID
DMNKC9J

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Clinical Trial Drug(s)
Drug(s) Targeting Cathepsin B (CTSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [2]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [2]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [2]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [2]
PMID27998201-Compound-11 DMTV5NU Metastatic cancer 2D50-2E2Z Patented [2]
PMID27998201-Compound-2 DMMAE3C Alzheimer disease 8A20 Patented [2]
PMID27998201-Compound-22 DMS9QA7 Alzheimer disease 8A20 Patented [2]
PMID27998201-Compound-13 DMZHIM8 Hepatic fibrosis DB93.0 Patented [2]
Dimethoxybenzylidene-2-thio-imidazole-4-one derivative 1 DMZ4B3W Cerebral ischemia 8B11 Patented [2]
PMID27998201-Compound-24 DM25BNZ Glioma 2A00.0 Patented [2]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin S (CTSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RG7625 DMDGPKS Autoimmune disease 4A40-4A45 Phase 2 [3]
SAR-114137 DMZ1XR5 Pain MG30-MG3Z Phase 1 [4]
VBY- 891 DMTKPH4 Autoimmune diabetes 5A10 Phase 1 [5]
VBY- 036 DMULRYC Neuropathic pain 8E43.0 Phase 1 [6]
VBY-129 DM4YIWK Autoimmune diabetes 5A10 Phase 1 [7]
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [2]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [2]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [2]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [8]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [2]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cathepsin B (CTSB) TTF2LRI CATB_HUMAN Inhibitor [1]
Cathepsin S (CTSS) TTUMQVO CATS_HUMAN Inhibitor [1]

References

1 Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68.
2 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353).
6 Clinical pipeline report, company report or official report of ViroBay.
7 Clinical pipeline report, company report or official report of ViroBay.
8 An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.