Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNMCQJ)

Drug Name

S-(3,4-Dichlorobenzyl)isothiourea hydrochloride Drug Info

Synonyms

22816-60-0; MreB Perturbing Compound A22; 2-(3,4-Dichloro-benzyl)-isothiourea hydrochloride; S-(3,4-Dichlorobenzyl)isothiourea, HCl; 3,4-dichlorobenzyl carbamimidothioate hydrochloride; 2-[(3,4-dichlorophenyl)methyl]isothiourea hydrochloride; 2-(3,4-DICHLORO-BENZYL)-ISOTHIOUREA; {[(3,4-dichlorophenyl)methyl]sulfanyl}methanimidamide hydrochloride; CHEMBL1224484; amino[(3,4-dichlorobenzyl)sulfanyl]methaniminium chloride; A 22 hydrochloride; AC1MD4YH

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2830968
CAS Number: CAS 22816-60-0
TTD Drug ID: DMNMCQJ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Indoleamine 2,3-dioxygenase 1 (IDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[2]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[3]
BMS-986205	DM3MAYQ	Melanoma	2C30	Phase 3	[4]
INCB24360	DMIJGT9	Urothelial carcinoma	2C92.0	Phase 3	[5]
NLG8189	DM0798Z	Melanoma	2C30	Phase 2/3	[4]
DN1406131	DMQFX8R	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
HTI-1090	DMI4TEC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
KHK2455	DMLSUQ8	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
LY3381916	DMONZ1L	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
PF-06840003	DMOX6EJ	Glioma	2A00.0	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Indoleamine 2,3-dioxygenase 1 (IDO1)	TTZJYKH	I23O1_HUMAN	Inhibitor	[1]

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References

1	S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9.
2	Interactions between nitric oxide and indoleamine 2,3-dioxygenase. Biochemistry. 2006 Jul 18;45(28):8527-38.
3	Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Incyte. Product Development Pipeline.
6	ClinicalTrials.gov (NCT03641794) Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Healthy Volunteers. U.S. National Institutes of Health.
7	Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation. J Enzyme Inhib Med Chem. 2019 Dec;34(1):250-263.
8	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)