Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNO20J)

Drug Name

mAb926 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Urinary tract infection	GC08	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Bacterial Fimbrin D-mannose adhesin (Bact FimH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EB8018	DM753H8	Crohn disease	DD70	Phase 2	[3]
GSK3882347	DM1DU20	Urinary tract infection	GC08	Phase 1	[4]
GSK3882347	DM1DU20	Urinary tract infection	GC08	Phase 1	[5]
Biaryl mannoside derivative 24	DMF5TB4	Crohn disease	DD70	Patented	[6]
PMID26651364-Compound-5	DMH7XL3	Crohn disease	DD70	Patented	[6]
PMID26651364-Compound-116	DMJ3201	Crohn disease	DD70	Patented	[6]
Biaryl mannoside derivative 8	DMWF2VG	Crohn disease	DD70	Patented	[6]
Beta-cyclodextrin conjugate derivative 3	DMQJF4P	Crohn disease	DD70	Patented	[6]
PMID26651364-Compound-109	DM01IWV	Crohn disease	DD70	Patented	[6]
PMID26651364-Compound-114	DM5GHJA	Crohn disease	DD70	Patented	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Fimbrin D-mannose adhesin (Bact FimH)	TTTCRU2	FIMH_ECOLI	Inhibitor	[2]

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References

1	Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471.
2	FimH as a scaffold for regulated molecular recognition. J Biol Eng. 2021 Jan 12;15(1):3.
3	Clinical pipeline report, company report or official report of Enterome Biosciences.
4	Clinical pipeline report, company report or official report of Fimbrion Therapeutics
5	Clinical pipeline report, company report or official report of GlaxoSmithKline
6	Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97.